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More women discontinue antihypertensive treatment than men

5 days ago

More women than men cease from taking their antihypertensive medication, as shown by the results of a recent study conducted in a real-life setting.

The investigators sought to compare persistence with antihypertensive drug therapy between men and women in a large cohort of patients. They identified a total of 60,526 residents of the Italian Lombardy Region, who were aged 40–80 years and newly treated with antihypertensive drugs during 2010, and followed them for 1 year after the first prescription.

Treatment discontinuation was defined as lack of prescription renewal for at least 90 days. The risk ratio of treatment discontinuation in relation to sex was estimated by fitting log-binomial regression models. Analyses were stratified according to age, comorbidity status and the initial antihypertensive treatment strategy.

Of the participants, 37 percent discontinued antihypertensive treatment during follow-up. The risk of treatment discontinuation was 10-percent (95 percent confidence interval, 8–12) lower in men than in women. In addition, men showed better adherence to antihypertensive treatment than women, and this was true in both younger (40–64 years) and older patients (65–80 years), in patients starting treatment with any major antihypertensive drug, and in patients with a low comorbidity status.

However, no evidence was found on whether men and women had a different risk of treatment discontinuation when their comorbidity status was worse or initial antihypertensive treatment was based on drug combinations.

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Most Read Articles
Pearl Toh, 03 Jan 2020
Antibiotic resistance of Helicobacter (H.) pylori has more than doubled in Europe in the past two decades, raising alarm on the gravity of the issue of growing bacterial resistance to commonly-used antibiotics, a study presented at UEG Week 2019 has shown.
02 Dec 2019
Utilizing a clinical pharmacist specialist in a hepatitis C virus (HCV) treatment clinic may help improve drug therapy management of HCV-infected patients treated with direct-acting antivirals (DAAs), suggests a recent study.
Pearl Toh, 26 Sep 2019
The Singapore Health Sciences Authority (HSA) has recalled eight brands of ranitidine products containing trace amounts of the nitrosamine impurity NDMA*, which is a potential human carcinogen.
4 days ago
The use of folic acid in addition to enalapril in the treatment of patients with hypertension yields a modest increase in lifetime stroke-free survival, a study has found.