Most Read Articles
06 Jul 2020
Routinely used for treating cardiovascular diseases, statins have been shown to benefit other conditions, and new evidence suggests that using the drug at high intensity reduces the risk of hip or knee replacement, an effect that may be specific to rheumatoid arthritis.
Pearl Toh, 29 Jun 2020
Having migraine during midlife appears to be associated with a higher risk of developing dementia in later life, according to a large population-based longitudinal Danish study presented at the AHS* 2020 Virtual Meeting, indicating that migraine may be a risk factor for dementia.
Roshini Claire Anthony, 5 days ago

Upadacitinib may be a suitable treatment for patients with active psoriatic arthritis (PsA) who have insufficient response to non-biologic disease-modifying anti-rheumatic drugs (non-bDMARDs), according to results of the phase III SELECT-PsA-1* trial presented at EULAR 2020.

5 days ago
Maternal stress during pregnancy correlates with rapid weight gain of her infant, a recent study has found.

More physical activity, less sedentary time may improve vascular ageing

30 May 2020

A recent study in the general Spanish population has shown that one in 10 has healthy vascular ageing (HVA) and one in five has early vascular ageing (EVA). Increasing physical activity, reducing sedentary time, and decreasing obesity and insulin resistance improve vascular ageing.

Random sampling was performed in recruiting a total of 501 participants (mean age, 55.90±14.24 years; 49.70 percent men).

There were three steps used to define vascular ageing: (Step 1) Participants with vascular damage in carotid arteries or peripheral artery disease were classified as EVA. (Step 2) Three criteria were used with the percentiles of carotid-to-femoral pulse wave velocity (cfPWV)—first, the 10th and 90th cfPWV percentiles of the population studied by age and sex; second, the 10th and 90th percentiles of the European population reference values; and third, the 25th and 75th cfPWV percentiles of the population studied by age and sex. (Step 3) Participants with hypertension or type 2 diabetes mellitus included in HVA were reclassified as normal vascular ageing.

The investigators examined arterial stiffness with cfPWV using a Sphygmocor device and measured physical activity with an accelerometer. Standard questionnaire was used to obtain psychological factors, lifestyle, and other clinical information.

Using criteria a and b, HVA had a global prevalence of 8 percent and 14 percent (men: 8 percent and 10 percent; women: 9 percent and 18 percent), and 22 percent and 18 percent (men: 26 percent and 23 percent; women: 17 percent and 12 percent), respectively.

Logistic regression analysis revealed the positive associations of vascular ageing with more sedentary time (odds ratio [OR], 2.37 and 4.51), having triglycerides >150 mg/dl (OR, 6.55 and 4.06), abdominal obesity (OR, 2.71 and 2.90), increased uric acid (OR, 4.63 and 2.98), and insulin resistance index homeostatic model assessment (OR, 4.05 and 6.78), as well as a negative association with less physical activity (OR, 0.29 and 0.28) using criteria a and b, respectively.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
06 Jul 2020
Routinely used for treating cardiovascular diseases, statins have been shown to benefit other conditions, and new evidence suggests that using the drug at high intensity reduces the risk of hip or knee replacement, an effect that may be specific to rheumatoid arthritis.
Pearl Toh, 29 Jun 2020
Having migraine during midlife appears to be associated with a higher risk of developing dementia in later life, according to a large population-based longitudinal Danish study presented at the AHS* 2020 Virtual Meeting, indicating that migraine may be a risk factor for dementia.
Roshini Claire Anthony, 5 days ago

Upadacitinib may be a suitable treatment for patients with active psoriatic arthritis (PsA) who have insufficient response to non-biologic disease-modifying anti-rheumatic drugs (non-bDMARDs), according to results of the phase III SELECT-PsA-1* trial presented at EULAR 2020.

5 days ago
Maternal stress during pregnancy correlates with rapid weight gain of her infant, a recent study has found.