Most Read Articles
18 May 2020
Immobilization or disuse of the forearm leads to impairment in the ability of a protein-rich meal to promote positive muscle amino acid balance, which is aggravated by dietary lipid oversupply, suggests a study. Disuse also lowers postprandial forearm amino acid uptake, but this is not exacerbated under high-fat conditions.
18 May 2020
Glucagon-like peptide-1 receptor agonists (GLP-1RA) are more effective than basal insulin in the management of total (TC) and low-density lipoprotein cholesterol (LDL-C), reveals a recent study.
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Increased coffee consumption among regular drinkers is associated with higher estimated glomerular filtration rate and confers protection against the risk of chronic kidney disease stages G3–G5 and albuminuria, as shown in a study.
Jairia Dela Cruz, 16 May 2020
Excess weight, greater abdominal fat, inflammation and low physical performance can all contribute to insulin resistance in middle-age Singaporean women, and these variables explain why the condition is more common among women of Chinese than Malay and Indian ethnicities, a study has found.

Mood stabilizers impact sexual functioning in patients with bipolar disorder

02 May 2020

Lithium treatment, alone or in combination with benzodiazepines, worsen sexual function (SF) in patients with bipolar disorder (BD), a recent study has shown.

Researchers conducted a multicentre, cross-sectional investigation of 114 BD patients who received lithium alone (L group), anticonvulsants alone (A group), lithium with anticonvulsants (L+A group) or lithium with benzodiazepines (L+B group). SF was measured according to the Changes in Sexual Functioning Questionnaire Short Form (CSFQ-14).

SF was significantly worse in the L (odds ratio [OR], 0.31, 95 percent confidence interval [CI], 0.11–0.90; p=0.032) and L+B (OR, 0.27, 95 percent CI, 0.080–0.89; p=0.032) groups relative to the A group. Other risk factors for poor SF were being female (OR, 0.19, 95 percent CI, 0.079–0.45; p<0.001) and older age (OR, 0.94, 95 percent CI, 0.90–0.98; p=0.006).

In terms of sexual desire, lithium alone (OR, 0.26, 95 percent CI, 0.09–0.74; p=0.012) or with benzodiazepines (OR, 0.20, 95 percent CI, 0.06–0.64; p=0.007) yielded significantly more negative effects than anticonvulsants. Lithium alone had the same effect on sexual arousal (OR, 0.32, 95 percent CI, 0.11–0.89; p=0.029).

In turn, these effects on SF correlated with changes in quality of life. For example, higher sexual arousal was associated with better physical (OR, 2.18, 95 percent CI, 0.24–4.12; p=0.028) and mental (OR, 2.85, 95 percent CI, 0.99–4.71; p=0.003) component summary scores.

“In other words, mood stabilizers affect SF differently, and depending on the affected phase of SF, QoL is also affected differently,” the researchers said.

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Most Read Articles
18 May 2020
Immobilization or disuse of the forearm leads to impairment in the ability of a protein-rich meal to promote positive muscle amino acid balance, which is aggravated by dietary lipid oversupply, suggests a study. Disuse also lowers postprandial forearm amino acid uptake, but this is not exacerbated under high-fat conditions.
18 May 2020
Glucagon-like peptide-1 receptor agonists (GLP-1RA) are more effective than basal insulin in the management of total (TC) and low-density lipoprotein cholesterol (LDL-C), reveals a recent study.
17 May 2020
Increased coffee consumption among regular drinkers is associated with higher estimated glomerular filtration rate and confers protection against the risk of chronic kidney disease stages G3–G5 and albuminuria, as shown in a study.
Jairia Dela Cruz, 16 May 2020
Excess weight, greater abdominal fat, inflammation and low physical performance can all contribute to insulin resistance in middle-age Singaporean women, and these variables explain why the condition is more common among women of Chinese than Malay and Indian ethnicities, a study has found.