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Mood, physical function tied to HRQoL in patients with brain metastases

28 May 2020

Mood, physical function, learning, and memory are important correlates of health-related quality of life (HRQoL) in patients with metastatic brain cancer, a new study has found.

The study included 93 patients (mean age, 58 years; 53 percent female) with newly diagnosed brain metastases who were asked to accomplish various cognitive batteries. Variables were collected from various domains, including cognitive, demographic, mood, treatment, and functioning. HRQoL was measured using the Functional Assessment of Cancer Treatment (FACT) scale.

Lung cancer was the most common primary malignancy, followed by breast cancer and melanoma. Most of the metastatic brain tumours were located in the frontal lobe.

Of all the domains of cognition, impairment was most common in verbal learning, memory, and phonemic verbal fluency. Researchers found that all aspects of HRQoL, except for emotional wellbeing, were significantly affected by at least one measure of memory and learning. Moreover, social wellbeing was also correlated with auditory attention and semantic fluency.

Mood factors, such as anxiety, depression, and overall mental health, were also significantly associated with HRQoL.

Regression analysis revealed that mood variables made up majority of the model for the prediction of the general FACT scores. They were accompanied by two nonmood variables: physical health and social support. Clinical and cognitive variables were precluded from the final model, although verbal memory emerged as an important predictor of cognitive wellbeing.

“Our findings suggest that clinicians must broaden conceptualizations of physical HRQoL to also include components of mood and mood-related assessments,” the researchers said. “Results of these assessments can then be used to tailor recommendations and referrals to help mitigate the impact that brain metastasis has on HRQOL.”

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Most Read Articles
5 days ago
Routinely used for treating cardiovascular diseases, statins have been shown to benefit other conditions, and new evidence suggests that using the drug at high intensity reduces the risk of hip or knee replacement, an effect that may be specific to rheumatoid arthritis.
Jairia Dela Cruz, 5 days ago
Following vegan and vegetarian diets, which offer plenty of what is good for health, has been reported to have a downside: an increased risk of depression and anxiety, especially for younger adults.
Pearl Toh, 29 Jun 2020
Having migraine during midlife appears to be associated with a higher risk of developing dementia in later life, according to a large population-based longitudinal Danish study presented at the AHS* 2020 Virtual Meeting, indicating that migraine may be a risk factor for dementia.
Roshini Claire Anthony, 3 days ago

Upadacitinib may be a suitable treatment for patients with active psoriatic arthritis (PsA) who have insufficient response to non-biologic disease-modifying anti-rheumatic drugs (non-bDMARDs), according to results of the phase III SELECT-PsA-1* trial presented at EULAR 2020.