Most Read Articles
22 Jul 2020
A picosecond alexandrite laser (PSAL) appears to be superior to Q-switched alexandrite laser (QSAL) for the treatment of nevus of Ota, as shown by its better clinical results and fewer adverse events, according to a study.
5 days ago
Supplementation with probiotics may have positive effects in patients with type 2 diabetes mellitus (T2DM), reports a recent meta-analysis.
4 days ago
Ensituximab, a chimeric monoclonal antibody targeting a variant of MUC5AC, shows modest clinical activity with good safety profile in patients with refractory colorectal cancer, according to data from a phase II study.
Roshini Claire Anthony, 6 days ago

Frailty may indicate an increased risk of death from COVID-19, results of the COPE* study showed.

Modified Kane formula trumps other IOL power formulas for keratoconus

3 days ago
The cornea, the transparent outermost layer of the eye, protects the eye from infection and physical injury.

The most accurate intraocular lens (IOL) power formula for patients with keratoconus is the modified Kane formula, while the SRK/T outdoes other traditional IOL power formulas, according to the results of a recent study.

In addition, all normal IOL formulas have resulted in hyperopic refractive outcomes that worsened as the corneal power increased.

This retrospective consecutive case series analysed data from 14 eyes of 147 patients with keratoconus who had preoperative IOLMaster biometry. A single eye for each eligible patient was randomly selected.

The authors then calculated the predicted refraction for each of the formulas (modified IOL power formulas: Holladay 2 with keratoconus adjustment and Kane keratoconus formula; traditional IOL power formulas: Barrett Universal 2, Haigis, Hoffer Q, Holladay 1, Holladay 2, Kane, and SRK/T) and compared these with the actual refractive outcome to show the prediction error.

Finally, a subgroup analysis was carried out based on the steepest corneal power measured by biometry (stage 1: ≤48 dioptres [D], stage 2: >48 D and ≤53 D, and stage 3: >53 D).

The following formulas were ranked based on the mean absolute prediction error (MAE): Kane keratoconus formula (0.81 D), SRK/T (1.00 D), Barrett Universal 2 (1.03 D), unmodified Kane (1.05 D), Holladay 1 (1.18 D), unmodified Holladay 2 (1.19 D), Haigis (1.22 D), Hoffer Q (1.30 D), and Holladay 2 with keratoconus adjustment (1.32 D).

The Kane keratoconus formula demonstrated a statistically significant lower MAE compared with all formulas, modified or otherwise (p<0.01). Furthermore, all nonmodified formulas had a hyperopic mean prediction error ranging from 1.72 to 3.02 D in stage 3 keratoconus.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
22 Jul 2020
A picosecond alexandrite laser (PSAL) appears to be superior to Q-switched alexandrite laser (QSAL) for the treatment of nevus of Ota, as shown by its better clinical results and fewer adverse events, according to a study.
5 days ago
Supplementation with probiotics may have positive effects in patients with type 2 diabetes mellitus (T2DM), reports a recent meta-analysis.
4 days ago
Ensituximab, a chimeric monoclonal antibody targeting a variant of MUC5AC, shows modest clinical activity with good safety profile in patients with refractory colorectal cancer, according to data from a phase II study.
Roshini Claire Anthony, 6 days ago

Frailty may indicate an increased risk of death from COVID-19, results of the COPE* study showed.