Most Read Articles
Stephen Padilla, 6 days ago
The novel coronavirus disease (COVID-19) pandemic appears to have a significant impact on oncological care, according to a study, which stresses the need for psycho-oncological support for cancer patients.
01 Aug 2020
Supplementation with probiotics may have positive effects in patients with type 2 diabetes mellitus (T2DM), reports a recent meta-analysis.
6 days ago
Sodium–glucose cotransporter-2 (SGLT-2) inhibitors increase the risk for diabetic ketoacidosis (DKA) by almost threefold, with molecule-specific analyses suggesting a class effect, according to a study.
Stephen Padilla, 2 days ago
Pre-exposure prophylaxis (PrEP) containing either long-acting injectable cabotegravir (CAB) or tenofovir/emtricitabine (TDF/FTC) is safe and effective for transgender women (TGW) and cisgender men who have sex with men (MSM), but CAB results in a much lower HIV incidence compared to TDF/FTC, results of the HIV Prevention Trials Network (HPTN) 083 have shown.

Modified Kane formula trumps other IOL power formulas for keratoconus

02 Aug 2020
The cornea, the transparent outermost layer of the eye, protects the eye from infection and physical injury.

The most accurate intraocular lens (IOL) power formula for patients with keratoconus is the modified Kane formula, while the SRK/T outdoes other traditional IOL power formulas, according to the results of a recent study.

In addition, all normal IOL formulas have resulted in hyperopic refractive outcomes that worsened as the corneal power increased.

This retrospective consecutive case series analysed data from 14 eyes of 147 patients with keratoconus who had preoperative IOLMaster biometry. A single eye for each eligible patient was randomly selected.

The authors then calculated the predicted refraction for each of the formulas (modified IOL power formulas: Holladay 2 with keratoconus adjustment and Kane keratoconus formula; traditional IOL power formulas: Barrett Universal 2, Haigis, Hoffer Q, Holladay 1, Holladay 2, Kane, and SRK/T) and compared these with the actual refractive outcome to show the prediction error.

Finally, a subgroup analysis was carried out based on the steepest corneal power measured by biometry (stage 1: ≤48 dioptres [D], stage 2: >48 D and ≤53 D, and stage 3: >53 D).

The following formulas were ranked based on the mean absolute prediction error (MAE): Kane keratoconus formula (0.81 D), SRK/T (1.00 D), Barrett Universal 2 (1.03 D), unmodified Kane (1.05 D), Holladay 1 (1.18 D), unmodified Holladay 2 (1.19 D), Haigis (1.22 D), Hoffer Q (1.30 D), and Holladay 2 with keratoconus adjustment (1.32 D).

The Kane keratoconus formula demonstrated a statistically significant lower MAE compared with all formulas, modified or otherwise (p<0.01). Furthermore, all nonmodified formulas had a hyperopic mean prediction error ranging from 1.72 to 3.02 D in stage 3 keratoconus.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Stephen Padilla, 6 days ago
The novel coronavirus disease (COVID-19) pandemic appears to have a significant impact on oncological care, according to a study, which stresses the need for psycho-oncological support for cancer patients.
01 Aug 2020
Supplementation with probiotics may have positive effects in patients with type 2 diabetes mellitus (T2DM), reports a recent meta-analysis.
6 days ago
Sodium–glucose cotransporter-2 (SGLT-2) inhibitors increase the risk for diabetic ketoacidosis (DKA) by almost threefold, with molecule-specific analyses suggesting a class effect, according to a study.
Stephen Padilla, 2 days ago
Pre-exposure prophylaxis (PrEP) containing either long-acting injectable cabotegravir (CAB) or tenofovir/emtricitabine (TDF/FTC) is safe and effective for transgender women (TGW) and cisgender men who have sex with men (MSM), but CAB results in a much lower HIV incidence compared to TDF/FTC, results of the HIV Prevention Trials Network (HPTN) 083 have shown.