Most Read Articles
Roshini Claire Anthony, 4 days ago

Beta-blockers could reduce mortality risk in patients with heart failure with reduced ejection fraction (HFrEF) and moderate or moderately-severe renal dysfunction without causing harm, according to the BB-META-HF* trial presented at ESC 2019.

Stephen Padilla, 6 days ago
Implementation of the collaborative care in a rheumatoid arthritis (RA) clinic has led to improvements in nonbiologic disease-modifying antirheumatic drugs (nb-DMARDs) optimization, adherence to safety recommendations on nb-DMARD monitoring and detection of adverse drug events in RA patients, according to a Singapore study.
Pearl Toh, 6 days ago
Use of menopausal hormone therapy (MHT) was associated with a significantly increased risk of invasive breast cancer, which became progressively greater with longer duration of use, a meta-analysis of worldwide prospective epidemiological studies has shown.
4 days ago
Blood pressure (BP) in children is influenced by early-life exposure to several chemicals, built environment and meteorological factors, suggests a study.

Modified FOLFOX6 tied to better tolerability, higher completion rates vs CAPOX

12 Oct 2018

The combination of 5-fluorouracil and oxaliplatin (mFOLFOX6), the most commonly used adjuvant treatment option for stage IIB and stage III colon cancer in British Columbia, results in better tolerability and higher treatment completion rates relative to capecitabine plus oxaliplatin (CAPOX), according to a recent study.

Included in the analysis were patients (n=306) with resected stage IIB or stage III colon cancer from five British Columbia Cancer Agency centres treated with CAPOX or mFOLFOX6. The authors collected protocol utilization rates, patient characteristics and toxicities of the two regimens and compared these by descriptive statistics.

The most commonly used regimen was mFOLFOX6, with a utilization rate of 69 percent. Patients in the CAPOX arm were younger (57 vs 62 years; p<0.01), but there were no other significant differences between the two groups.

Compared to CAPOX, mFOLFOX6 was associated with less dose-limiting toxicities (82 percent vs 95 percent; p<0.01). In addition, more patients completed the intended 24-week course of mFOLFOX6 compared to CAPOX (82 percent vs 67 percent; p<0.01).

However, a study by Ho and colleagues found that replacing mFOLFOX6 with CAPOX in the adjuvant treatment of colon cancer was associated with potential cost savings from the payer and societal perspectives. [Clin Colorectal Cancer 2016;15:158-163]

From the payer perspective, CAPOX use led to cost savings of $5,339 CAD per patient vs use of mFOLFOX6. From a societal perspective, CAPOX use resulted in savings of $6,080 CAD per patient. The biggest cost savings with CAPOX were attributed to fewer visits for chemotherapy treatment and reduced usage of the central venous access device. [Clin Colorectal Cancer 2016;15:158-163]

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Most Read Articles
Roshini Claire Anthony, 4 days ago

Beta-blockers could reduce mortality risk in patients with heart failure with reduced ejection fraction (HFrEF) and moderate or moderately-severe renal dysfunction without causing harm, according to the BB-META-HF* trial presented at ESC 2019.

Stephen Padilla, 6 days ago
Implementation of the collaborative care in a rheumatoid arthritis (RA) clinic has led to improvements in nonbiologic disease-modifying antirheumatic drugs (nb-DMARDs) optimization, adherence to safety recommendations on nb-DMARD monitoring and detection of adverse drug events in RA patients, according to a Singapore study.
Pearl Toh, 6 days ago
Use of menopausal hormone therapy (MHT) was associated with a significantly increased risk of invasive breast cancer, which became progressively greater with longer duration of use, a meta-analysis of worldwide prospective epidemiological studies has shown.
4 days ago
Blood pressure (BP) in children is influenced by early-life exposure to several chemicals, built environment and meteorological factors, suggests a study.