Most Read Articles
Pearl Toh, 22 Oct 2020
The combination therapy comprising carfilzomib, cyclophosphamide and dexamethasone (KCd) is effective, with a tolerable safety profile, in an Asian cohort with high-risk multiple myeloma (MM) — thus providing a more economical alternative as a potential upfront regimen in resource-limited settings, according to leading experts during a myeloma education webinar.
Pearl Toh, 21 Sep 2020
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
3 days ago
Weight suppression appears to result in future onset of eating disorders characterized by dietary restriction or compensatory weight control behaviours, suggesting weight-suppressed women represent an at-risk group that may benefit from selective prevention programmes, a study has found.
4 days ago
Nocturia is a risk factor for mortality, according to the results of the Nagahama Study, which boasts of a low incidence of missing data and high representation of the general population.

Moderate-to-vigorous physical activity cardioprotective in lupus patients

25 Dec 2019

Physical activities (PA) of moderate-to-vigorous intensity confer protection against cardiovascular risk factors in patients with systemic lupus erythematosus (SLE), a study has found.

Researchers measured time in sedentary behaviour, light PA and moderate-to-vigorous PA (MVPA) in 100 SLE patients (mean age, 52.4 years; 92 percent female) who were free of cardiovascular disease (CVD) using accelerometry. They also assessed cardiovascular risk factors were measured, including body mass index (BMI), blood pressure, fasting glucose and lipid profile.

Accelerometer data showed that the mean total sedentary time was 10 hours/day, and the time spent in MVPA was low at a mean of 33.2 minutes/day. Only 11 participants met current PA recommendations (150 MVPA minutes/week in 10-minute bouts).

The 10-year risk of CVD (estimated using the American College of Cardiology/American Heart Association risk assessment tool) was low in the majority of patients (80 percent), intermediate in 14 patients and high in six patients.

Isotemporal substitution models revealed that when 10 minutes of sedentary behaviour were reallocated to MVPA, there were significant reductions observed in systolic (β, –2.15 mm Hg; p=0.01) and diastolic blood pressure (β, –1.56 mm Hg; p=0.01), as well as in estimated 10-year CVD risk (relative rate [RR], 0.81, 95 percent confidence interval [CI], 0.70–0.93).

Furthermore, time reallocation from light PA to MVPA led to lower diastolic blood pressure (β, –1.45 mm Hg; p=0.01) and 10-year CVD risk estimates (RR, 0.80, 95 percent CI, 0.69–0.94).

In light of the findings, PA interventions should address suboptimal MVPA levels to improve cardiovascular risk in the SLE population, according to the researchers.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Pearl Toh, 22 Oct 2020
The combination therapy comprising carfilzomib, cyclophosphamide and dexamethasone (KCd) is effective, with a tolerable safety profile, in an Asian cohort with high-risk multiple myeloma (MM) — thus providing a more economical alternative as a potential upfront regimen in resource-limited settings, according to leading experts during a myeloma education webinar.
Pearl Toh, 21 Sep 2020
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
3 days ago
Weight suppression appears to result in future onset of eating disorders characterized by dietary restriction or compensatory weight control behaviours, suggesting weight-suppressed women represent an at-risk group that may benefit from selective prevention programmes, a study has found.
4 days ago
Nocturia is a risk factor for mortality, according to the results of the Nagahama Study, which boasts of a low incidence of missing data and high representation of the general population.