Most Read Articles
Tristan Manalac, 6 days ago
Atopic dermatitis appears to impair sleep quality, but not sleep duration, in children, particularly in those with more severe diseases, according to a new study.
13 Mar 2019
Individuals following a diet low in or free of meat are at lower risk of diabetes, and this protective association is partly attributable to having a lower body mass index when compared with regular meat eaters, according to a study.
4 days ago
Drinking coffee confers benefits for recurrence of hepatocellular carcinoma (HCC) and survival following orthotopic liver transplantation, a study has found.
5 days ago
A recent study has shown that the short-term efficacy of tenofovir disoproxil fumarate (TDF) is superior to entecavir (ETV) for the treatment of acute-on-chronic-liver failure (ACLF) due to reactivation of chronic hepatitis B (CHB).

Misoprostol effective for healing small bowel ulcers in aspirin users

20 Oct 2018

Misoprostol promotes the healing of small bowel ulcers in aspirin users whose condition is complicated by small bowel bleeding, reports a recent trial.

Researchers enrolled 84 aspirin users with small bowel bleeding who were then randomly assigned to receive either 200 µg of misoprostol four times per day (n=42; mean age 73.0±8.79 years; 54.8 percent male) or placebo (n=42; mean age 70.2±11.89 years; 61.9 percent male). The trial lasted 8 weeks, during which the participants continued taking aspirin.

Capsule endoscopy showed that 28.6 percent (n=12) of patients in the misoprostol group demonstrated complete healing of small bowel ulcers with or without red spots. This was significantly higher than that in the placebo group (9.5 percent; n=4; difference in proportion, 19.0 percent; 95 percent CI, 2.8–35.3; p=0.026).

The medium number of ulcer/erosions significantly dropped from baseline in both the misoprostol (6.5 to 2; p<0.001) and placebo (7 to 4; p=0.003) groups. However, when compared with each other, misoprostol was significantly superior in producing such reductions (p=0.005).

A similar trend was observed for haemoglobin levels. Both groups showed significant improvements from baseline (misoprostol: 9.6±2.11 to 12.1±1.73 mg/dL; p<0.001; placebo: 9.5±2.28 to 11.3±1.68 mg/dL; p<0.001), though the between-group difference achieved statistical significance in favour of misoprostol (mean difference, 0.70 mg/dL; 0.05–1.36; p=0.035).

In terms of safety, gastrointestinal events were more frequently observed in the misoprostol group, though only one patient had to withdraw from the study due to diarrhoea.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Tristan Manalac, 6 days ago
Atopic dermatitis appears to impair sleep quality, but not sleep duration, in children, particularly in those with more severe diseases, according to a new study.
13 Mar 2019
Individuals following a diet low in or free of meat are at lower risk of diabetes, and this protective association is partly attributable to having a lower body mass index when compared with regular meat eaters, according to a study.
4 days ago
Drinking coffee confers benefits for recurrence of hepatocellular carcinoma (HCC) and survival following orthotopic liver transplantation, a study has found.
5 days ago
A recent study has shown that the short-term efficacy of tenofovir disoproxil fumarate (TDF) is superior to entecavir (ETV) for the treatment of acute-on-chronic-liver failure (ACLF) due to reactivation of chronic hepatitis B (CHB).