Most Read Articles
09 Jan 2019
Despite comparable efficacies, triamcinolone injections appear to be slightly superior over 5-fluorouracil injections for inducing keloid remission, a recent trial has found.
Jairia Dela Cruz, 6 days ago
Use of standard-dose aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs) appears to confer protection against the risk of endometrial cancer in overweight and obese women, according to a meta-analysis.
Tristan Manalac, 6 days ago
Less than 15 percent of Singaporean adolescents get the recommended 8–10 hours of sleep on a school night, reports a recent study, noting that such short sleep duration is linked to symptoms of depression, overweight or obesity, and poorer self-rated health.
04 Jan 2019
Obstructive sleep apnoea may increase the risk of male-pattern baldness in men with a family history of hair loss, and this association appears to be mediated by low serum transferrin saturation levels related to hypoxia, a study suggests.

Misoprostol effective for healing small bowel ulcers in aspirin users

20 Oct 2018

Misoprostol promotes the healing of small bowel ulcers in aspirin users whose condition is complicated by small bowel bleeding, reports a recent trial.

Researchers enrolled 84 aspirin users with small bowel bleeding who were then randomly assigned to receive either 200 µg of misoprostol four times per day (n=42; mean age 73.0±8.79 years; 54.8 percent male) or placebo (n=42; mean age 70.2±11.89 years; 61.9 percent male). The trial lasted 8 weeks, during which the participants continued taking aspirin.

Capsule endoscopy showed that 28.6 percent (n=12) of patients in the misoprostol group demonstrated complete healing of small bowel ulcers with or without red spots. This was significantly higher than that in the placebo group (9.5 percent; n=4; difference in proportion, 19.0 percent; 95 percent CI, 2.8–35.3; p=0.026).

The medium number of ulcer/erosions significantly dropped from baseline in both the misoprostol (6.5 to 2; p<0.001) and placebo (7 to 4; p=0.003) groups. However, when compared with each other, misoprostol was significantly superior in producing such reductions (p=0.005).

A similar trend was observed for haemoglobin levels. Both groups showed significant improvements from baseline (misoprostol: 9.6±2.11 to 12.1±1.73 mg/dL; p<0.001; placebo: 9.5±2.28 to 11.3±1.68 mg/dL; p<0.001), though the between-group difference achieved statistical significance in favour of misoprostol (mean difference, 0.70 mg/dL; 0.05–1.36; p=0.035).

In terms of safety, gastrointestinal events were more frequently observed in the misoprostol group, though only one patient had to withdraw from the study due to diarrhoea.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
09 Jan 2019
Despite comparable efficacies, triamcinolone injections appear to be slightly superior over 5-fluorouracil injections for inducing keloid remission, a recent trial has found.
Jairia Dela Cruz, 6 days ago
Use of standard-dose aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs) appears to confer protection against the risk of endometrial cancer in overweight and obese women, according to a meta-analysis.
Tristan Manalac, 6 days ago
Less than 15 percent of Singaporean adolescents get the recommended 8–10 hours of sleep on a school night, reports a recent study, noting that such short sleep duration is linked to symptoms of depression, overweight or obesity, and poorer self-rated health.
04 Jan 2019
Obstructive sleep apnoea may increase the risk of male-pattern baldness in men with a family history of hair loss, and this association appears to be mediated by low serum transferrin saturation levels related to hypoxia, a study suggests.