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Roshini Claire Anthony, 3 days ago

Patients with mild hypertension who are at low risk for cardiovascular disease (CVD) do not appear to derive mortality or CVD benefit from antihypertensive treatments, raising questions on the need for treatment in this population, according to a recent study from England.

Pearl Toh, 5 days ago
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Misoprostol effective for healing small bowel ulcers in aspirin users

20 Oct 2018

Misoprostol promotes the healing of small bowel ulcers in aspirin users whose condition is complicated by small bowel bleeding, reports a recent trial.

Researchers enrolled 84 aspirin users with small bowel bleeding who were then randomly assigned to receive either 200 µg of misoprostol four times per day (n=42; mean age 73.0±8.79 years; 54.8 percent male) or placebo (n=42; mean age 70.2±11.89 years; 61.9 percent male). The trial lasted 8 weeks, during which the participants continued taking aspirin.

Capsule endoscopy showed that 28.6 percent (n=12) of patients in the misoprostol group demonstrated complete healing of small bowel ulcers with or without red spots. This was significantly higher than that in the placebo group (9.5 percent; n=4; difference in proportion, 19.0 percent; 95 percent CI, 2.8–35.3; p=0.026).

The medium number of ulcer/erosions significantly dropped from baseline in both the misoprostol (6.5 to 2; p<0.001) and placebo (7 to 4; p=0.003) groups. However, when compared with each other, misoprostol was significantly superior in producing such reductions (p=0.005).

A similar trend was observed for haemoglobin levels. Both groups showed significant improvements from baseline (misoprostol: 9.6±2.11 to 12.1±1.73 mg/dL; p<0.001; placebo: 9.5±2.28 to 11.3±1.68 mg/dL; p<0.001), though the between-group difference achieved statistical significance in favour of misoprostol (mean difference, 0.70 mg/dL; 0.05–1.36; p=0.035).

In terms of safety, gastrointestinal events were more frequently observed in the misoprostol group, though only one patient had to withdraw from the study due to diarrhoea.

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Most Read Articles
Roshini Claire Anthony, 3 days ago

Patients with mild hypertension who are at low risk for cardiovascular disease (CVD) do not appear to derive mortality or CVD benefit from antihypertensive treatments, raising questions on the need for treatment in this population, according to a recent study from England.

Pearl Toh, 5 days ago
A personalized computerized neurofeedback intervention for training attention and memory shows potential in cognitive training for healthy elderly men, who improved in cognitive performance after the training, although no significant improvements were seen in the overall study population.
4 days ago
The simple Atrial fibrillation (AF) Better Care (ABC) pathway holistically updates the integrated care for AF patients and helps reduce the risk of adverse outcomes such as all-cause mortality, stroke/major bleeding/cardiovascular death and hospitalization, according to a study.
Yesterday
Type 1 diabetes impairs cognitive functioning in children, and this effect is exacerbated by extreme glycaemic levels, according to a recent meta-analysis.