Most Read Articles
2 days ago
Chest pain appears to be the principal complaint of patients hospitalized with a first myocardial infarction (MI), particularly among those in the youngest age group, a study has found.
Jairia Dela Cruz, 16 Sep 2020
In patients with heart failure with reduced ejection fraction (HFrEF) receiving angiotensin-converting-enzyme (ACE) inhibitors, high dosing confers benefits for the risk of death or hospitalization that are similar to that obtained with lower dosing, according to a systematic review and meta-analysis.
Pearl Toh, 2 days ago
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
3 days ago
Women with pre-eclampsia are at higher risk of developing heart failure, a study suggests.

Misdiagnosis of early gastric cancer characteristics, type leads to overtreatment

19 Nov 2019

Tumour diameter, depth and histological type are correlated with overtreatment with surgery in patients with early gastric cancer (EGC), a recent study has found.

Researchers performed a retrospective analysis of 781 EGC patients (median age, 68 years; 72.5 percent male) who were treated with surgical resection. Postoperative outcomes were used to determine whether patients indeed needed surgery or were overtreated. Predictive factors assessed included tumour diameter, depth, ulcerative diagnoses and main histology.

More than a quarter were identified to have been overtreated (28.7 percent; n=224). Almost half of the patients were misdiagnosed in terms of ulcerative findings (49.6 percent) and depth (40.7 percent). Misdiagnosis of histological type (14.7 percent) and tumour diameter (5.1 percent) were much rarer.

Comparison according to treatment appropriateness showed that misdiagnosis of tumour diameter (14.7 percent vs 1.3 percent), depth (75.9 percent vs 26.6 percent) and main cancer histology (24.1 percent vs 11.0 percent) were all significantly over-represented in patients who were overtreated with surgery.

These were confirmed in multivariate analysis. Misdiagnosis of tumour diameter (odds ratio [OR], 19.8, 95 percent confidence intervals [CI], 7.5–52.2; p<0.0001), depth (OR, 15.0, 95 percent CI, 9.6–23.8) and histology (OR, 6.1, 95 percent CI, 3.5–10.6; p<0.0001) were all significant predictors of overtreatment with surgery.

The findings indicate that there is a need to exercise greater care before prescribing endoscopic submucosal dissection for EGC patients, said researchers. Employing additional diagnostic techniques could be helpful toward this end.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Oncology - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
2 days ago
Chest pain appears to be the principal complaint of patients hospitalized with a first myocardial infarction (MI), particularly among those in the youngest age group, a study has found.
Jairia Dela Cruz, 16 Sep 2020
In patients with heart failure with reduced ejection fraction (HFrEF) receiving angiotensin-converting-enzyme (ACE) inhibitors, high dosing confers benefits for the risk of death or hospitalization that are similar to that obtained with lower dosing, according to a systematic review and meta-analysis.
Pearl Toh, 2 days ago
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
3 days ago
Women with pre-eclampsia are at higher risk of developing heart failure, a study suggests.