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Natalia Reoutova, 21 Nov 2019

Final analysis of the POEMS (Prevention of Early Menopause) study finds that breast cancer (BC) patients treated with the gonadotrophin-releasing hormone agonist (GnRHa) goserelin, in addition to chemotherapy, are more likely to avoid premature menopause and to become pregnant without negatively impacting disease-related outcomes.

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Misdiagnosis of early gastric cancer characteristics, type leads to overtreatment

19 Nov 2019

Tumour diameter, depth and histological type are correlated with overtreatment with surgery in patients with early gastric cancer (EGC), a recent study has found.

Researchers performed a retrospective analysis of 781 EGC patients (median age, 68 years; 72.5 percent male) who were treated with surgical resection. Postoperative outcomes were used to determine whether patients indeed needed surgery or were overtreated. Predictive factors assessed included tumour diameter, depth, ulcerative diagnoses and main histology.

More than a quarter were identified to have been overtreated (28.7 percent; n=224). Almost half of the patients were misdiagnosed in terms of ulcerative findings (49.6 percent) and depth (40.7 percent). Misdiagnosis of histological type (14.7 percent) and tumour diameter (5.1 percent) were much rarer.

Comparison according to treatment appropriateness showed that misdiagnosis of tumour diameter (14.7 percent vs 1.3 percent), depth (75.9 percent vs 26.6 percent) and main cancer histology (24.1 percent vs 11.0 percent) were all significantly over-represented in patients who were overtreated with surgery.

These were confirmed in multivariate analysis. Misdiagnosis of tumour diameter (odds ratio [OR], 19.8, 95 percent confidence intervals [CI], 7.5–52.2; p<0.0001), depth (OR, 15.0, 95 percent CI, 9.6–23.8) and histology (OR, 6.1, 95 percent CI, 3.5–10.6; p<0.0001) were all significant predictors of overtreatment with surgery.

The findings indicate that there is a need to exercise greater care before prescribing endoscopic submucosal dissection for EGC patients, said researchers. Employing additional diagnostic techniques could be helpful toward this end.

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Most Read Articles
Natalia Reoutova, 21 Nov 2019

Final analysis of the POEMS (Prevention of Early Menopause) study finds that breast cancer (BC) patients treated with the gonadotrophin-releasing hormone agonist (GnRHa) goserelin, in addition to chemotherapy, are more likely to avoid premature menopause and to become pregnant without negatively impacting disease-related outcomes.

Dr. Jay Zhu, Dr. Lai Fung Li, Prof. Chae-Yong Kim, 27 Nov 2019
The current standard of care for glioblastoma multiforme (GBM), an aggressive primary brain tumour with a rapid disease course, consists of maximum safe surgical resection followed by radiotherapy with concomitant temozolomide (TMZ) chemotherapy and subsequent TMZ maintenance. At the 16th Annual Meeting of the Asian Society of Neuro-Oncology (ASNO) in Taipei, Taiwan, experts reviewed the evidence and shared their clinical experience on the use of tumour treating fields (TTFields), a novel treatment modality for GBM.