Most Read Articles
4 days ago
The use of capsule endoscopy (CE) appears to be effective in the diagnosis of iron deficiency anaemia (IDA), yielding a 33.9-percent yield in this study, with 65.8 percent of patients undergoing further workup and 12.7 percent requiring therapeutic intervention.
Tristan Manalac, 3 days ago
Minimally invasive pancreatectomy (MIP) offers a feasible alternative to open pancreatectomy (OP) for the treatment of pancreatic neuroendocrine neoplasms (PNEN), according to a recent Singapore study has found.
Yesterday
The perception that proton pump inhibitors (PPIs) cause multiple serious adverse effects (AEs) is supported by many internists, who then recommend treatment cessation even in patients at high risk for upper gastrointestinal bleeding (UGIB), reveals a study.
21 May 2020
At the 13th Annual Scientific Meeting of the Malaysian Osteoporosis Society (MOS), Dr Chan Siew Pheng discussed the role of alfacalcidol (One-Alpha®) in the treatment of osteoporosis (OP) and presented several patient profiles where alfacalcidol exhibited efficacy in increasing bone mineral density (BMD).

MiRNA‐4508 a potential diagnostic biomarker for silica‐related pulmonary fibrosis

16 May 2020

MicroRNA-4508 shows promise as a diagnostic marker for silica-related pulmonary fibrosis (SPF), while its functional variant rs6576457 has been shown to influence susceptibility to SPF, according to a study.

A comprehensive miRNA sequencing screening was carried out in peripheral blood leukocytes of eight individuals exposed to silica dust (four with SPF and four healthy controls). Then, the investigators examined the promising miRNA in the first-stage validation using an independent GEO data set (GSE80555) of six participants (three with SPF and three healthy controls). This was followed by a second-stage validation in 120 individuals exposed to silica dust (60 with SPF and 60 healthy controls).

Thirty-five miRNA demonstrated robust expression differences in miRNA-seq screening. After the first-stage validation (GSE80555), miRNA-4508 (p=9.52 x 10-3) was retained as a candidate. The second-stage validation confirmed this, showing similar and strong effect (p=9.93 x 10-17). In receiver operating characteristic (ROC) analysis, miRNA-4508 distinguished SPF cases from healthy controls with high area under the ROC curve (0.886; sensitivity, 81.7 percent; specificity, 86.7 percent).

Furthermore, a robust association was observed between the miRNA-4508 upstream rs6576457 mutant A allele and susceptibility to SPF (odds ratio, 1.64, 95 percent confidence interval, 1.20–3.32; p=0.002). In expression quantitative trait loci analysis, a potential association was seen between different genotypes of rs6576457 and miRNA-4508 expression (p=0.068) in 60 healthy individuals with exposure to silica dust.

“The detailed mechanism of action of this miRNA remains to be elucidated,” the investigators noted.

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Most Read Articles
4 days ago
The use of capsule endoscopy (CE) appears to be effective in the diagnosis of iron deficiency anaemia (IDA), yielding a 33.9-percent yield in this study, with 65.8 percent of patients undergoing further workup and 12.7 percent requiring therapeutic intervention.
Tristan Manalac, 3 days ago
Minimally invasive pancreatectomy (MIP) offers a feasible alternative to open pancreatectomy (OP) for the treatment of pancreatic neuroendocrine neoplasms (PNEN), according to a recent Singapore study has found.
Yesterday
The perception that proton pump inhibitors (PPIs) cause multiple serious adverse effects (AEs) is supported by many internists, who then recommend treatment cessation even in patients at high risk for upper gastrointestinal bleeding (UGIB), reveals a study.
21 May 2020
At the 13th Annual Scientific Meeting of the Malaysian Osteoporosis Society (MOS), Dr Chan Siew Pheng discussed the role of alfacalcidol (One-Alpha®) in the treatment of osteoporosis (OP) and presented several patient profiles where alfacalcidol exhibited efficacy in increasing bone mineral density (BMD).