Most Read Articles
Roshini Claire Anthony, 6 days ago

For coffee drinkers, drinking filtered coffee may be tied to a lower mortality risk, including cardiovascular disease (CVD)-related mortality, a study from Norway suggested.

Stephen Padilla, 28 May 2020
Use of noninvasive ventilation (NIV), similar to invasive mechanical ventilation (IMV), appears to lessen mortality but may increase the risk for transmission of the novel coronavirus disease (COVID-19) in healthcare workers, suggest the results of a study.
3 days ago
Use of corticosteroid is not associated with improved outcomes in idiopathic pulmonary fibrosis (IPF) patients admitted to the hospital with acute exacerbation (AE), reveals a recent study. In addition, corticosteroids may even contribute to reduced overall survival following exacerbation.
Dr. Wong Soon Tee, 28 May 2020
Acne is a common skin problem seen in primary care. Dr Wong Soon Tee of Assurance Skin Clinic at Mt Elizabeth Novena Hospital, Singapore shares his insights with Pearl Toh on how to manage acne in the primary care setting.

Mirikizumab shows promise in ulcerative colitis

27 Feb 2020

Mirikizumab, a monoclonal antibody targeting interleukin-23, induces clinical response in ulcerative colitis (UC) patients in 12 weeks, a recent study has found.

Researchers randomly assigned patients with moderate to severely active UC to receive intravenous mirikizumab 50 mg (n=63; mean age, 41.8±14.1 years; 39.7 percent female) or 200 mg (n=62; mean age, 43.4±14.7 years; 40.3 percent female) with exposure-based dosing, mirikizumab 600 mg (n=61; mean age, 42.4±13.4 years; 37.7 percent female) with fixed dosing, or placebo (n=63; mean age, 42.6±13.5 years; 42.9 percent female). Clinical remission at week 12 was the primary endpoint.

Around 73 percent and 44 percent of patients taking the 50-mg and 200-mg medication had their doses adjusted, such that the overall average doses in these groups during the 12-week study period were 100 and 250 mg, respectively.

Only three patients (4.8 percent) in the placebo group achieved clinical remission by week 12, whereas ten patients (15.9 percent, 95 percent confidence interval [CI], 6.8–24.9; p=0.066) did in the 50-mg group.

On the other hand, 14 (22.6 percent; 95 percent CI, 12.2–33.0; p=0.004) and seven (11.5 percent; 95 percent CI, 3.5–19.4; p=0.142) patients taking the 200-mg and 600-mg mirikizumab doses showed clinical remission.

Clinical response rates were 41.3 percent, 59.7 percent and 49.2 percent in the 50-mg, 200-mg and 600-mg mirikizumab groups, respectively, as compared to only 20.6 percent in placebo patients.

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Most Read Articles
Roshini Claire Anthony, 6 days ago

For coffee drinkers, drinking filtered coffee may be tied to a lower mortality risk, including cardiovascular disease (CVD)-related mortality, a study from Norway suggested.

Stephen Padilla, 28 May 2020
Use of noninvasive ventilation (NIV), similar to invasive mechanical ventilation (IMV), appears to lessen mortality but may increase the risk for transmission of the novel coronavirus disease (COVID-19) in healthcare workers, suggest the results of a study.
3 days ago
Use of corticosteroid is not associated with improved outcomes in idiopathic pulmonary fibrosis (IPF) patients admitted to the hospital with acute exacerbation (AE), reveals a recent study. In addition, corticosteroids may even contribute to reduced overall survival following exacerbation.
Dr. Wong Soon Tee, 28 May 2020
Acne is a common skin problem seen in primary care. Dr Wong Soon Tee of Assurance Skin Clinic at Mt Elizabeth Novena Hospital, Singapore shares his insights with Pearl Toh on how to manage acne in the primary care setting.