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29 Nov 2019
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Mirabegron-solifenacin combo safe, effective for overactive bladder

21 Nov 2019

Mirabegron in combination with solifenacin is effective against overactive bladder (OAB) and comes with a good tolerability profile, a recent study has shown.

Researchers conducted a literature search of the databases of Embase, Cochrane and Medline for studies reporting on the efficacy and safety of antimuscarinic agents either in combination with each other or with a β3-adrenoreceptor agonists for OAB. Twenty-one publications, one of which was a conference abstract, were deemed eligible for inclusion.

One phase II trial was included, which employed a double-blind, placebo- and monotherapy-controlled, dose-ranging design. Compared with 5-mg solifenacin monotreatment, all combinations of 5- and 10-mg solifenacin with any dose of mirabegron resulted in significantly better mean volume voided per micturition.

Three combinations―10-mg solifenacin and 25-mg mirabegron, 5-mg solifenacin and 50-mg mirabegron, and 10-mg solifenacin and 50-mg mirabegron―significantly reduced micturition frequency from baseline. Aside from a slightly elevated frequency of constipation in patients treated with combination medication, no significant treatment-emergent adverse events were reported.

Three phase III/IIIb trials of mirabegron with solifenacin were included. Taken together, these studies showed that in treatment-naïve patients, the combination of solifenacin with mirabegron successfully reduced urinary incontinence episodes and micturitions relative to corresponding monotherapy doses.

The combination was also effective in those with initially inadequate responses to solifenacin alone and received mirabegron as an add-on.

These improvements in medication efficacy did not come with significant tradeoff, as no adverse event occurred with a significantly greater frequency in those receiving combination intervention.

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Most Read Articles
29 Nov 2019
Metformin Extended Release 500 mg,750 mg, and 1000 mg
Pearl Toh, Yesterday
Getting just under one extra hour of sleep per night can go a long way for the health of college students, who are often sleep-deprived, a study suggests.
29 Nov 2019
Saxagliptin 5 mg, dapagliflozin 10 mg FC tab
Roshini Claire Anthony, 5 days ago

The CA125* test could be useful at detecting ovarian cancer and various other cancers in the primary care setting, particularly for women aged >50 years, according to a study presented at the recent NCRI** Cancer Conference held in Glasgow, Scotland, UK.