Most Read Articles
03 Sep 2018
Dietary nicotinamide riboside (NR) supplementation in 2,000-mg doses daily over a 12-week period is safe, a recent study has shown. However, it does not improve insulin sensitivity and whole-body glucose metabolism in obese, insulin-resistant men.
07 Apr 2016
Radha Chitale spoke with Dr. Kim A. Williams, Sr., who served as the 2015-2016 president of the American College of Cardiology, during the organization's annual meeting in Chicago, Illinois, US as he reflected on his term and discussed what's exciting in cardiology. 
Dr. Joseph Delano Fule Robles, 25 Jul 2018

Prior to considering pharmacotherapy or surgery, weight reduction can be achieved through dietary modification and management of meal habits, sleep hours and stress.

Minimal extrathyroid extension ups recurrence risk in differentiated thyroid cancer

10 Jul 2018

The risk of recurrence for differentiated thyroid cancer (DTC) escalates in patients with minimal extrathyroid extension (mETE), but the absolute increase in risk is small, according to a recent study.

Additionally, the risk is within the low-risk of recurrence category at 3.5 percent in patients without lymph node involvement (N0 disease). mETE confers no effect on disease-related mortality and should not change tumour stage.

The authors performed a meta-analysis of controlled trials comparing DTC patients with and without mETE to examine the impact of mETE on patient outcomes. A total of 13 retrospective studies including 23,816 patients met the inclusion criteria, with a median follow-up of 86 months.

In patients with N0 disease, mETE correlated with increased risk of recurrence (seven studies: odds ratio [OR], 1.73; 95 percent CI, 1.03–2.92). The absolute risk of recurrence was 2.2 percent and 3.5 percent in patients without and with mETE, respectively (p=0.04).

Studies involving patients with and without lymph node involvement showed mETE to be associated with a significantly higher risk of recurrence (eight studies: OR, 1.82; 1.14–2.91). The absolute risk of recurrence was 6.2 percent and 7 percent in patients without and with mETE, respectively (p=0.01).

mETE had nonsignificant impact (OR, 2.40; 0.95–6.03) in patients with micropapillary carcinoma, while no impact was seen on disease-related mortality (eight studies: OR, 0.5; 0.11–2.21).

“mETE in patients with DTC was defined as an intermediate risk feature in the 2015 American Thyroid Association guidelines. However, controversy persists as several studies suggested mETE has little effect on disease outcome,” the authors said.

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Most Read Articles
03 Sep 2018
Dietary nicotinamide riboside (NR) supplementation in 2,000-mg doses daily over a 12-week period is safe, a recent study has shown. However, it does not improve insulin sensitivity and whole-body glucose metabolism in obese, insulin-resistant men.
07 Apr 2016
Radha Chitale spoke with Dr. Kim A. Williams, Sr., who served as the 2015-2016 president of the American College of Cardiology, during the organization's annual meeting in Chicago, Illinois, US as he reflected on his term and discussed what's exciting in cardiology. 
Dr. Joseph Delano Fule Robles, 25 Jul 2018

Prior to considering pharmacotherapy or surgery, weight reduction can be achieved through dietary modification and management of meal habits, sleep hours and stress.