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14 Aug 2018
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Although many patients with atopic dermatitis (AD) use antihistamines, no high-level evidence exists to prove that nonsedating antihistamines reduce itch in patients with AD or provide benefit in controlling AD symptoms, except perhaps sleep and AD comorbidities such as allergic rhinitis, according to a study.

Miniaturized percutaneous nephrostolithotomy reduces blood loss after renal stone removal

29 Apr 2018

Conventional and miniaturized percutaneous nephrostolithotomy (mini-PCNL) are similarly effective in removing renal stones 1–3.5 cm, but blood loss is lower in mini-PCNL, a recent study has shown.

After a single procedure, 66 percent of the participants who underwent mini-PCNL were declared stone-free, similar to the 63 percent in the patients who received conventional PCNL. Initial stone volume was comparable between groups (p=0.14), but stone density was significantly greater in the mini-PCNL group (1,149±406 vs 877±386 HU; p=0.014).

Residual stone volume (0.64±1.6 vs s0.49±1.2 cm3; p=0.70), postoperative analgesic use (19.1±20.8 vs 21.1±15.2 morphine equivalents; p=0.70) and operative time (121±41 vs 124±36 minutes; p=0.74) were all statistically similar between the conventional and mini-PCNL groups. An equal number of patients from each group required a second procedure.

In comparison, the volume of blood loss was significantly lower in participants who underwent mini-PCNL vs conventional PCNL (0.90±1.3 vs 1.7±0.84; p=0.02). No blood transfusions were performed in either group.

“We do not believe mini-PCNL will replace conventional PCNL in removing large branched or staghorn calculi, but it is a viable alternative for removing stones up to 3.5 cm,” said researchers, as most of the clinical and efficacy endpoints were similar between the two procedures.

“This quality improvement study shows the single advantage of mini-PCNL was less blood loss,” they added

Researchers compared the outcomes of 29 patients (mean age 53.1±15.8 years; 19 male) who received mini-PCNL with that of 27 patients (mean age 55.5±15.3; 9 male) who had conventional PCNL. For inclusion, maximum stone size was 3.5 cm. All operations were performed by a single surgeon.

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Most Read Articles
14 Aug 2018
Patients with coronary artery disease (CAD) treated in a poor Southeast Asian setting appear to have far too high short-term and medium-term mortality rates, according to a study.
2 days ago
Despite the absence of a substance use problem, regular cannabis use is associated with psychosocial impairment among adolescents and young adults, a study suggests. On the other hand, regular users with cannabis use disorder appear to exhibit high psychiatric comorbidity and more severe psychosocial impairment.
4 days ago
Heeding the advice to eat more vegetables has led to an increase in consumption above the Australian Dietary recommendation of ~375 g/day among overweight participants, a recent study has shown. Tomatoes are a common choice regardless of the time of year, but selections change over time.
21 Jul 2018
Although many patients with atopic dermatitis (AD) use antihistamines, no high-level evidence exists to prove that nonsedating antihistamines reduce itch in patients with AD or provide benefit in controlling AD symptoms, except perhaps sleep and AD comorbidities such as allergic rhinitis, according to a study.