Most Read Articles
20 Jun 2020
The Lundbeck Neuroscience Symposium was held at Sofitel KL Damansara over 2 days, with extensivediscussions on the management of various mental illnesses. The second day of the symposiumaddressed the topic of schizophrenia management, focusing on treatment goals, the rationale forpartial dopamine D(2) receptor agonism and the use of long-acting injectable (LAI) antipsychotics topromote adherence.
Pearl Toh, 3 days ago
Having migraine during midlife appears to be associated with a higher risk of developing dementia in later life, according to a large population-based longitudinal Danish study presented at the AHS* 2020 Virtual Meeting, indicating that migraine may be a risk factor for dementia.
2 days ago
Patients with psoriatic arthritis (PsA) often suffer from liver abnormalities, which are associated with higher body mass index (BMI), daily consumption of alcohol, more severe disease, and some therapies, according to a recent study.
Christina Lau, Yesterday

Pembrolizumab in combination with chemotherapy significantly improves progression-free survival (PFS) vs chemotherapy alone in patients with previously untreated, locally recurrent inoperable or metastatic triple-negative breast cancer (TNBC), results of the KEYNOTE-355 study have shown.

Mineralocorticoid receptor antagonists confer antiproteinuric effect in CKD

13 Dec 2019

Treatment with mineralocorticoid receptor antagonists (MRA) alone or in addition to renin–angiotensin system (RAS) blockade is associated with significant antiproteinuric effects, with a slight increase in mean potassium levels, in patients with chronic kidney disease (CKD), a study has shown.

A systematic review and meta-analysis was conducted to determine the effects of MRAs on albuminuria/proteinuria and adverse events, such as change in renal function and hyperkalaemia incidence. The investigators searched electronic databases, clinical trial registries and grey literature to retrieve randomized controlled trials (RCTs) that compared MRA alone or on top of RAS blockade with placebo or active treatment.

Forty-five studies with a total of 2,767 participants were initially identified, of which 31 were included in the analysis.

Compared with placebo, MRAs (alone or with RAS blockade) reduced urine albumin-to-creatinine ratio (UACR) by –24.55 percent (95 percent confidence interval [CI], –29.57 to –19.53 percent), urine protein-to-creatinine ratio by –53.93 percent (95 percent CI, –79 to –28.86 percent) and 24-h albumin excretion by –32.47 percent (95 percent CI, –41.1 to –23.85 percent).

MRAs, compared with calcium-channel blockers, also reduced UACR by –22.48 percent (95 percent CI, –24.51 to –20.44 percent), but there were no differences when compared with a second RAS blockade or nonpotassium-sparing diuretics.

The addition of an MRA resulted in a change in estimated glomerular filtration rate of –2.38 ml/min per 1.73 m2 (95 percent CI, −3.51 to −1.25), an increase in potassium by 0.22 mEq/l (95 percent CI, 0.16–0.28 mEq/l) and a 2.6-fold rise in the risk of hyperkalaemia (risk ratio, 2.63, 95 percent CI, 1.69–4.08) compared with placebo or active control.

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Most Read Articles
20 Jun 2020
The Lundbeck Neuroscience Symposium was held at Sofitel KL Damansara over 2 days, with extensivediscussions on the management of various mental illnesses. The second day of the symposiumaddressed the topic of schizophrenia management, focusing on treatment goals, the rationale forpartial dopamine D(2) receptor agonism and the use of long-acting injectable (LAI) antipsychotics topromote adherence.
Pearl Toh, 3 days ago
Having migraine during midlife appears to be associated with a higher risk of developing dementia in later life, according to a large population-based longitudinal Danish study presented at the AHS* 2020 Virtual Meeting, indicating that migraine may be a risk factor for dementia.
2 days ago
Patients with psoriatic arthritis (PsA) often suffer from liver abnormalities, which are associated with higher body mass index (BMI), daily consumption of alcohol, more severe disease, and some therapies, according to a recent study.
Christina Lau, Yesterday

Pembrolizumab in combination with chemotherapy significantly improves progression-free survival (PFS) vs chemotherapy alone in patients with previously untreated, locally recurrent inoperable or metastatic triple-negative breast cancer (TNBC), results of the KEYNOTE-355 study have shown.