Most Read Articles
Tee Hoi Poh, 26 Sep 2018
Stool-based colorectal cancer (CRC) screening should be the preferred method of CRC screening in Malaysia, according to Dato Dr Muhammad Radzi Abu Hassan, the Head of Gastroenterology Services in Ministry of Health, Malaysia, who presented the Malaysian experience on CRC screening at the Annual Scientific Meeting of the Society of Gastroenterology and Hepatology (GUT) 2018 held recently in Penang.
Jackey Suen, 26 Nov 2018

Linagliptin has no impact on cognitive decline when given on top of standard of care in patients with type 2 diabetes mellitus (T2DM), a CARMELINA substudy has shown.

Mild cognitive impairment less likely to develop in obese, diabetic women than men

12 Sep 2018

Among obese and overweight adults with type 2 diabetes mellitus (T2DM), women appear to be less likely than men to develop mild cognitive impairment (MCI), independent of traditional risk factors, a recent study has shown.

Researchers cross-sectionally analysed 3,802 adults (2,323 women), of whom 99 percent (n=3,771) underwent cognitive assessments. Majority were between the ages of 55 and 64 years (males: 57.1 percent; females: 56.7 percent), had body mass index (BMI) values between 30 and 39 kg/m2 (males: 60.4 percent; females: 65.6 percent).

Cognitive status was evaluated at a mean of 11.4 years after study enrolment. MCI was reported in 6.9 percent (n=159) of women and 12.3 percent (n=179) of men, while dementia was observed in 1.4 percent (n=32) of women and 2.5 percent (n=36) of men.

After adjusting for covariates such as age, education and ethnicity, researchers showed that the likelihood of MCI or dementia was significantly lower in females (odds ratio [OR], 0.55; 95 percent CI, 0.43–0.71; p<0.001). The risk of dementia alone was nonsignificantly lower (OR, 0.79; 0.47–1.33; p=0.37).

Stepwise logistic regression analysis was performed to develop a multivariable risk factor model, which yielded the following set of predictors: age, history of cardiovascular disease, education level and depressive symptoms. Controlling for these factors did not attenuate the significantly reduced MCI risk in women (OR, 0.60; 0.47–0.76; p<0.001).

Accounting for changes in weight and physical activity over time also did not significantly affect the interaction (OR, 0.54; 0.36–0.83; pp=0.004).

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Most Read Articles
Tee Hoi Poh, 26 Sep 2018
Stool-based colorectal cancer (CRC) screening should be the preferred method of CRC screening in Malaysia, according to Dato Dr Muhammad Radzi Abu Hassan, the Head of Gastroenterology Services in Ministry of Health, Malaysia, who presented the Malaysian experience on CRC screening at the Annual Scientific Meeting of the Society of Gastroenterology and Hepatology (GUT) 2018 held recently in Penang.
Jackey Suen, 26 Nov 2018

Linagliptin has no impact on cognitive decline when given on top of standard of care in patients with type 2 diabetes mellitus (T2DM), a CARMELINA substudy has shown.