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Pearl Toh, 20 Apr 2018
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Mild cognitive impairment less likely to develop in obese, diabetic women than men

12 Sep 2018

Among obese and overweight adults with type 2 diabetes mellitus (T2DM), women appear to be less likely than men to develop mild cognitive impairment (MCI), independent of traditional risk factors, a recent study has shown.

Researchers cross-sectionally analysed 3,802 adults (2,323 women), of whom 99 percent (n=3,771) underwent cognitive assessments. Majority were between the ages of 55 and 64 years (males: 57.1 percent; females: 56.7 percent), had body mass index (BMI) values between 30 and 39 kg/m2 (males: 60.4 percent; females: 65.6 percent).

Cognitive status was evaluated at a mean of 11.4 years after study enrolment. MCI was reported in 6.9 percent (n=159) of women and 12.3 percent (n=179) of men, while dementia was observed in 1.4 percent (n=32) of women and 2.5 percent (n=36) of men.

After adjusting for covariates such as age, education and ethnicity, researchers showed that the likelihood of MCI or dementia was significantly lower in females (odds ratio [OR], 0.55; 95 percent CI, 0.43–0.71; p<0.001). The risk of dementia alone was nonsignificantly lower (OR, 0.79; 0.47–1.33; p=0.37).

Stepwise logistic regression analysis was performed to develop a multivariable risk factor model, which yielded the following set of predictors: age, history of cardiovascular disease, education level and depressive symptoms. Controlling for these factors did not attenuate the significantly reduced MCI risk in women (OR, 0.60; 0.47–0.76; p<0.001).

Accounting for changes in weight and physical activity over time also did not significantly affect the interaction (OR, 0.54; 0.36–0.83; pp=0.004).

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Most Read Articles
Pearl Toh, 20 Apr 2018
The investigational oral synthetic androgen dimethandrolone undecanoate (DMAU) suppresses serum testosterone levels to near castrate levels and appears safe when taken once daily for a month, showing potential as a male contraceptive pill, according to a study.
02 Aug 2018
Men and women who regularly eat seafood appear to have higher sexual intercourse frequency (SIF) and fecundity in a large prospective cohort of couples attempting pregnancy, suggests a study.
08 Oct 2018
Plasma trimethylamine-N-oxide (TMAO) concentrations are positively associated with gestational diabetes mellitus (GDM), according to the findings of a phase II study.
12 Apr 2018
In the context of low-glycaemic index (GI) dietary patterns, eating pasta does not contribute to adiposity and may even reduce body weight and body mass index (BMI) compared with higher-GI dietary patterns, a recent study has found.