Most Read Articles
Roshini Claire Anthony, 29 May 2020

For coffee drinkers, drinking filtered coffee may be tied to a lower mortality risk, including cardiovascular disease (CVD)-related mortality, a study from Norway suggested.

3 days ago
Use of metformin is effective in preventing hyperglycaemia in nondiabetic cancer patients exposed to high-dose prednisone-based chemotherapy, results of a randomized study have shown.
6 days ago
Use of corticosteroid is not associated with improved outcomes in idiopathic pulmonary fibrosis (IPF) patients admitted to the hospital with acute exacerbation (AE), reveals a recent study. In addition, corticosteroids may even contribute to reduced overall survival following exacerbation.
Dr. Wong Soon Tee, 28 May 2020
Acne is a common skin problem seen in primary care. Dr Wong Soon Tee of Assurance Skin Clinic at Mt Elizabeth Novena Hospital, Singapore shares his insights with Pearl Toh on how to manage acne in the primary care setting.

Migraine with aura signals acute ICH in Dutch-type cerebral amyloid angiopathy

19 Mar 2020

Migraine attacks herald the first symptomatic intracerebral haemorrhage (ICH) in most individuals with Dutch-type cerebral amyloid angiopathy (D-CAA), although such attacks do not predict an earlier onset of first haemorrhage, as shown in a recent study.

The study included 86 D-CAA mutation carriers (mean age, 57 years; 57 percent female), among whom 48 (56 percent) had migraine, all with aura. Researchers scored magnetic resonance imaging (MRI) scans for ICH location(s) and presence of cortical superficial siderosis.

Prevalence of migraine in D-CAA was higher than in the general population (women, p<0.05; men, p<0.001). Migraine preceded the first symptomatic ICH in 37 (77 percent) carriers, while it was an isolated symptom in 17 (35 percent). Carriers with vs without migraine did not significantly differ in terms of age and medical history.

Migraine onset occurred a median of 8.5 years before first ICH. Aura attacks lasting ≥60 minutes signaled acute ICH in 55 percent. More than half of D-CAA carriers experienced their first migraine attack after the third decade of life. The mean age at which carriers with migraine experienced their first ICH was similar to those without migraine.

Migraine with aura was associated with neither occipital ICH nor cortical superficial siderosis on MRI.

The findings indicate that migraine with aura may be regarded as an early marker of disease in hereditary CAA preceding the occurrence of symptomatic ICH by several years, according to the researchers.

Editor's Recommendations
Most Read Articles
Roshini Claire Anthony, 29 May 2020

For coffee drinkers, drinking filtered coffee may be tied to a lower mortality risk, including cardiovascular disease (CVD)-related mortality, a study from Norway suggested.

3 days ago
Use of metformin is effective in preventing hyperglycaemia in nondiabetic cancer patients exposed to high-dose prednisone-based chemotherapy, results of a randomized study have shown.
6 days ago
Use of corticosteroid is not associated with improved outcomes in idiopathic pulmonary fibrosis (IPF) patients admitted to the hospital with acute exacerbation (AE), reveals a recent study. In addition, corticosteroids may even contribute to reduced overall survival following exacerbation.
Dr. Wong Soon Tee, 28 May 2020
Acne is a common skin problem seen in primary care. Dr Wong Soon Tee of Assurance Skin Clinic at Mt Elizabeth Novena Hospital, Singapore shares his insights with Pearl Toh on how to manage acne in the primary care setting.