MicroRNA expression levels tied to survival in oesophageal carcinoma
Tissue expression levels of several microRNAs (miRNA) are significantly associated with overall survival in patients with oesophageal carcinoma (EC), a recent meta-analysis has shown.
Researchers accessed the databases of Pubmed, Embase, Cochrane and Web of Science for studies that evaluated the prognostic value of miRNA expression levels in EC patients. The selection criteria resulted in 44 eligible articles, yielding a cumulative sample of 4,310 EC patients, in whom expression of 22 miRNAs was measured.
A pooled analysis of 10 studies showed that high tissue expression levels of miR-21 was associated with significantly poorer overall survival (hazard ratio [HR], 1.63; 95 percent CI, 1.26–2.11; p<0.01). The same was true of miR-203 tissue expression, which was quantified in two studies (HR, 2.83; 1.35–5.95; p<0.01).
In comparison, reduced expression levels of miR-375 (six studies; HR, 1.64; 1.05–2.58; p=0.03), miR-133a (two studies; HR, 2.48; 1.50–4.12; p<0.01), miR-133b (two studies; HR, 2.15; 1.27–3.26; p<0.01) and miR-138 (two studies; HR, 2.27; 1.68–3.08; p<0.01) were correlated with significantly shorter overall survival.
Levels of miRNAs in the blood likewise correlated with overall survival. High blood miR-21 (HR, 2.19; 1.31–3.68; p<0.01) and low blood miR-223 (HR, 1.62; 1.12–2.34; p=0.01) were linked to significantly worse overall survival.
“Combined detection of multiple microRNA levels could be used by clinical workers and other healthcare providers, which might greatly augment the ability to estimate survival time of EC patients so that timely treatment could be provided,” said researchers.