Most Read Articles
5 days ago
A strong belief in the necessity of medication is associated with better adherence to oral disease-modifying antirheumatic drugs (DMARDs) or prednisone, while higher self-efficacy correlates with poor adherence, in a diverse cohort of patients with rheumatoid arthritis (RA), suggests a study.
4 days ago
Low-dose administrations of haloperidol after thoracic surgery does not appear to prevent postoperative delirium, according to a new study.
2 days ago
Percutaneous coronary intervention (PCI) displays comparable rates of mortality and serious composite outcomes but a higher rate of target-vessel revascularization at 10 years relative to coronary artery bypass grafting (CABG) in patients with significant left main coronary artery (LMCA) disease, reports a study. On the other hand, CABG delivers lower mortality and serious composite outcome rates compared with PCI with drug-eluting stents after 5 years.
Pearl Toh, 4 days ago
Apixaban slashes the risk of recurrent venous thromboembolism (VTE) by 90 percent in cancer patients compared with the low-molecular-weight heparin (LMWH) dalteparin, with no increase in major bleeding risk, according to the ADAM VTE study presented at ASH 2018.

MicroRNA expression levels tied to survival in oesophageal carcinoma

5 days ago

Tissue expression levels of several microRNAs (miRNA) are significantly associated with overall survival in patients with oesophageal carcinoma (EC), a recent meta-analysis has shown.

Researchers accessed the databases of Pubmed, Embase, Cochrane and Web of Science for studies that evaluated the prognostic value of miRNA expression levels in EC patients. The selection criteria resulted in 44 eligible articles, yielding a cumulative sample of 4,310 EC patients, in whom expression of 22 miRNAs was measured.

A pooled analysis of 10 studies showed that high tissue expression levels of miR-21 was associated with significantly poorer overall survival (hazard ratio [HR], 1.63; 95 percent CI, 1.26–2.11; p<0.01). The same was true of miR-203 tissue expression, which was quantified in two studies (HR, 2.83; 1.35–5.95; p<0.01).

In comparison, reduced expression levels of miR-375 (six studies; HR, 1.64; 1.05–2.58; p=0.03), miR-133a (two studies; HR, 2.48; 1.50–4.12; p<0.01), miR-133b (two studies; HR, 2.15; 1.27–3.26; p<0.01) and miR-138 (two studies; HR, 2.27; 1.68–3.08; p<0.01) were correlated with significantly shorter overall survival.

Levels of miRNAs in the blood likewise correlated with overall survival. High blood miR-21 (HR, 2.19; 1.31–3.68; p<0.01) and low blood miR-223 (HR, 1.62; 1.12–2.34; p=0.01) were linked to significantly worse overall survival.

“Combined detection of multiple microRNA levels could be used by clinical workers and other healthcare providers, which might greatly augment the ability to estimate survival time of EC patients so that timely treatment could be provided,” said researchers.

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Most Read Articles
5 days ago
A strong belief in the necessity of medication is associated with better adherence to oral disease-modifying antirheumatic drugs (DMARDs) or prednisone, while higher self-efficacy correlates with poor adherence, in a diverse cohort of patients with rheumatoid arthritis (RA), suggests a study.
4 days ago
Low-dose administrations of haloperidol after thoracic surgery does not appear to prevent postoperative delirium, according to a new study.
2 days ago
Percutaneous coronary intervention (PCI) displays comparable rates of mortality and serious composite outcomes but a higher rate of target-vessel revascularization at 10 years relative to coronary artery bypass grafting (CABG) in patients with significant left main coronary artery (LMCA) disease, reports a study. On the other hand, CABG delivers lower mortality and serious composite outcome rates compared with PCI with drug-eluting stents after 5 years.
Pearl Toh, 4 days ago
Apixaban slashes the risk of recurrent venous thromboembolism (VTE) by 90 percent in cancer patients compared with the low-molecular-weight heparin (LMWH) dalteparin, with no increase in major bleeding risk, according to the ADAM VTE study presented at ASH 2018.