Most Read Articles
5 days ago
Combining the DASH (Dietary Approaches to Stop Hypertension) diet with low sodium intake reduces systolic blood pressure (SBP) in individuals with pre- and stage 1 hypertension, with progressively higher reductions at greater levels of baseline SBP, a recent study has shown.
Tristan Manalac, 3 days ago
Major depressive disorder (MDD) appears to be more prevalent in females than in males, particularly in those who are divorced or widowed, a recent study from Singapore has found.
4 days ago
Tadalafil may not be effective for reducing the decline in ambulatory ability in boys with Duchenne muscular dystrophy (DMD), as shown in a recent study.
01 Dec 2017
At a symposium during the 25th Congress of the Obstetrical and Gynaecological Society of Malaysia in Kuala Lumpur, Professor Susan Davis discussed the unique implications of women living decades beyond menopause, and how healthcare professionals can best manage menopausal symptoms in the short and long term.

Micronutrient levels vary in patients with Down syndrome

13 Aug 2017

Patients with Down syndrome (DS) have lower blood concentrations of zinc, selenium and calcium, and higher blood cell levels of copper and zinc, according to a systematic review.

Studies that measured micronutrient levels in whole blood, hair, saliva, red cell, serum and plasma samples of DS patients and controls were searched from the databases of PubMed, Web of Knowledge and Scopus. Those that measured protein and mRNA expression were excluded. A total of 69 studies met the inclusion criteria.

The Newcastle-Ottawa scale was used to assess methodological quality of the eligible observational studies. Information extracted from the studies included type of specimen, study sample characteristics, assay used and micronutrient levels.

Five comparisons (cases n=83; controls n=125) showed that red blood cell (RBC) levels of copper were significantly higher in patients with DS than in controls (standardized mean difference [SMD], 2.77; 95 percent CI, 1.96 to 3.57; p<0.00001).

Selenium concentration in the blood (SMD, -0.99; -1.55 to -0.43; p=0.0006), serum (SMD, -0.60; -0.97 to -0.23; p=0.001) and whole blood (SMD, -2.60; -3.32 to -1.89; p<0.00001) were significantly lower in DS cases.

Additionally, while blood calcium was significantly lower in DS cases (SMD, -0.63; -1.16 to -0.09; p=0.02), salivary levels were significantly higher (SMD, 0.85; 0.38 to 1.33; p=0.0004). Salivary sodium was significantly elevated in DS cases (SMD, 1.04; 0.39 to 1.69; p=0.002).

Blood (SMD, -1.30; -1.75 to -0.84; p<0.00001), plasma (SMD, -1.23; -1.93 to -0.54; p=0.0005), serum (SMD, -1.44; -1.93 to -0.95; p<0.00001) and hair (SMD, -0.54; -0.97 to -0.12; p=0.01) zinc concentrations were significantly lower in patients with DS, while RBC zinc (SMD, 2.62; 1.59 to 3.66; p<0.00001) was higher.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
DOWNLOAD
Editor's Recommendations
Most Read Articles
5 days ago
Combining the DASH (Dietary Approaches to Stop Hypertension) diet with low sodium intake reduces systolic blood pressure (SBP) in individuals with pre- and stage 1 hypertension, with progressively higher reductions at greater levels of baseline SBP, a recent study has shown.
Tristan Manalac, 3 days ago
Major depressive disorder (MDD) appears to be more prevalent in females than in males, particularly in those who are divorced or widowed, a recent study from Singapore has found.
4 days ago
Tadalafil may not be effective for reducing the decline in ambulatory ability in boys with Duchenne muscular dystrophy (DMD), as shown in a recent study.
01 Dec 2017
At a symposium during the 25th Congress of the Obstetrical and Gynaecological Society of Malaysia in Kuala Lumpur, Professor Susan Davis discussed the unique implications of women living decades beyond menopause, and how healthcare professionals can best manage menopausal symptoms in the short and long term.