Most Read Articles
Pearl Toh, 2 days ago
First-line therapy with the BTK* inhibitor ibrutinib plus the anti-CD20 immunotherapy rituximab confers significant survival advantage over the current gold-standard regimen of fludarabine, cyclophosphamide, and rituximab (FCR) for young, fit patients with treatment-naïve chronic lymphocytic leukaemia (CLL), according to the E1912 trial, a large cooperative group study supported by the US National Cancer Institute.
5 days ago
Percutaneous coronary intervention (PCI) displays comparable rates of mortality and serious composite outcomes but a higher rate of target-vessel revascularization at 10 years relative to coronary artery bypass grafting (CABG) in patients with significant left main coronary artery (LMCA) disease, reports a study. On the other hand, CABG delivers lower mortality and serious composite outcome rates compared with PCI with drug-eluting stents after 5 years.
Pearl Toh, 07 Dec 2018
Apixaban slashes the risk of recurrent venous thromboembolism (VTE) by 90 percent in cancer patients compared with the low-molecular-weight heparin (LMWH) dalteparin, with no increase in major bleeding risk, according to the ADAM VTE study presented at ASH 2018.
Yesterday
Rates of major bleeding events are similar across cancer patients taking direct oral anticoagulants (DOAC), low-molecular-weight heparin (LMWH) or vitamin K antagonist (VKA), with gastrointestinal bleeding being the most frequent event, a recent study has shown. In addition, DOAC and LMWH recorded higher rates of venous thromboembolism than earlier studies.

Microbiological findings affect hyponatraemia incidence among children with respiratory infections

01 Dec 2018

In children, the incidence rate of hyponatraemia differs according to the respiratory tract infection and the invading microorganism, a recent study has shown.

In 3,938 children (mean age 22.9±21.7 months; 55.7 percent male), 13.5 percent (n=531) had hyponatraemia. Majority had interstitial pneumonia (50.2 percent); 4.5 percent (n=177) had upper respiratory tract infections, 18.4 percent (n=724) had acute bronchiolitis and 24.6 (n=969) had acute bronchitis.

Hyponatraemia incidence varied significantly according to radiologic findings (p<0.0001), such that the condition was most common in children with upper respiratory tract infection (44.1 percent). In comparison, incidence was lowest in patients with acute bronchitis (10.5 percent) and acute bronchiolitis (9.7 percent).

Microbiological findings were also significantly associated with hyponatraemia (p=0.001). Children positive for two or three organisms demonstrated a higher hyponatraemia rate than those with monoinfections. In the hyponatraemia group, coinfections were significantly more common than in the no-condition group (p=0.001).

Multiple logistic regression analysis further showed that age (odds ratio [OR], 1.007; 95 percent CI, 1.002–1.012; p=0.006), the male sex (OR, 1.361; 1.105–1.675; p=0.004) and C-reactive protein levels (OR, 1.093; 1.060–1.128; p<0.0001) were all significantly associated with the development of hyponatraemia in children.

In comparison, coinfection with different organisms was strongly correlated, but achieved only borderline significance (OR, 3.493; 0.814–14.998; p=0.092).

In the present study, multiplex reverse transcription polymerase chain reaction was used on nasopharyngeal isolates for the detection of microorganisms. Other laboratory and radiologic information were collected upon study admission.

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Most Read Articles
Pearl Toh, 2 days ago
First-line therapy with the BTK* inhibitor ibrutinib plus the anti-CD20 immunotherapy rituximab confers significant survival advantage over the current gold-standard regimen of fludarabine, cyclophosphamide, and rituximab (FCR) for young, fit patients with treatment-naïve chronic lymphocytic leukaemia (CLL), according to the E1912 trial, a large cooperative group study supported by the US National Cancer Institute.
5 days ago
Percutaneous coronary intervention (PCI) displays comparable rates of mortality and serious composite outcomes but a higher rate of target-vessel revascularization at 10 years relative to coronary artery bypass grafting (CABG) in patients with significant left main coronary artery (LMCA) disease, reports a study. On the other hand, CABG delivers lower mortality and serious composite outcome rates compared with PCI with drug-eluting stents after 5 years.
Pearl Toh, 07 Dec 2018
Apixaban slashes the risk of recurrent venous thromboembolism (VTE) by 90 percent in cancer patients compared with the low-molecular-weight heparin (LMWH) dalteparin, with no increase in major bleeding risk, according to the ADAM VTE study presented at ASH 2018.
Yesterday
Rates of major bleeding events are similar across cancer patients taking direct oral anticoagulants (DOAC), low-molecular-weight heparin (LMWH) or vitamin K antagonist (VKA), with gastrointestinal bleeding being the most frequent event, a recent study has shown. In addition, DOAC and LMWH recorded higher rates of venous thromboembolism than earlier studies.