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Microbiological findings affect hyponatraemia incidence among children with respiratory infections

01 Dec 2018

In children, the incidence rate of hyponatraemia differs according to the respiratory tract infection and the invading microorganism, a recent study has shown.

In 3,938 children (mean age 22.9±21.7 months; 55.7 percent male), 13.5 percent (n=531) had hyponatraemia. Majority had interstitial pneumonia (50.2 percent); 4.5 percent (n=177) had upper respiratory tract infections, 18.4 percent (n=724) had acute bronchiolitis and 24.6 (n=969) had acute bronchitis.

Hyponatraemia incidence varied significantly according to radiologic findings (p<0.0001), such that the condition was most common in children with upper respiratory tract infection (44.1 percent). In comparison, incidence was lowest in patients with acute bronchitis (10.5 percent) and acute bronchiolitis (9.7 percent).

Microbiological findings were also significantly associated with hyponatraemia (p=0.001). Children positive for two or three organisms demonstrated a higher hyponatraemia rate than those with monoinfections. In the hyponatraemia group, coinfections were significantly more common than in the no-condition group (p=0.001).

Multiple logistic regression analysis further showed that age (odds ratio [OR], 1.007; 95 percent CI, 1.002–1.012; p=0.006), the male sex (OR, 1.361; 1.105–1.675; p=0.004) and C-reactive protein levels (OR, 1.093; 1.060–1.128; p<0.0001) were all significantly associated with the development of hyponatraemia in children.

In comparison, coinfection with different organisms was strongly correlated, but achieved only borderline significance (OR, 3.493; 0.814–14.998; p=0.092).

In the present study, multiplex reverse transcription polymerase chain reaction was used on nasopharyngeal isolates for the detection of microorganisms. Other laboratory and radiologic information were collected upon study admission.

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Most Read Articles
5 days ago
Living a sedentary lifestyle may increase the risk of cardiovascular diseases (CVD) even in people with healthy body mass index (BMI), reports a new study.
04 Feb 2019
The carbon-chain length of saturated fatty acids appears to be an important factor in determining its role in cardiovascular health, a recent study has found.
3 days ago
Olanzapine confers a modest therapeutic effect on weight compared with placebo in adult outpatients with anorexia nervosa, a study has shown. However, it does not appear to offer significant benefit for psychological symptoms.
Jairia Dela Cruz, 04 Feb 2019
Treatment with secukinumab results in a higher rate of remission or low-disease activity at week 16 in patients with psoriatic arthritis as compared with placebo, according to a posthoc analysis of the FUTURE 2 study. This effect is sustained at 2 years and is evident in both tumour necrosis factor inhibitor-experienced and -naïve patients.