Most Read Articles
06 Dec 2018
A strong belief in the necessity of medication is associated with better adherence to oral disease-modifying antirheumatic drugs (DMARDs) or prednisone, while higher self-efficacy correlates with poor adherence, in a diverse cohort of patients with rheumatoid arthritis (RA), suggests a study.
Pearl Toh, Yesterday
First-line therapy with the BTK* inhibitor ibrutinib plus the anti-CD20 immunotherapy rituximab confers significant survival advantage over the current gold-standard regimen of fludarabine, cyclophosphamide, and rituximab (FCR) for young, fit patients with treatment-naïve chronic lymphocytic leukaemia (CLL), according to the E1912 trial, a large cooperative group study supported by the US National Cancer Institute.
6 days ago
Low-dose administrations of haloperidol after thoracic surgery does not appear to prevent postoperative delirium, according to a new study.
4 days ago
Percutaneous coronary intervention (PCI) displays comparable rates of mortality and serious composite outcomes but a higher rate of target-vessel revascularization at 10 years relative to coronary artery bypass grafting (CABG) in patients with significant left main coronary artery (LMCA) disease, reports a study. On the other hand, CABG delivers lower mortality and serious composite outcome rates compared with PCI with drug-eluting stents after 5 years.

Methotrexate only as good as placebo in preventing UC relapse

03 Aug 2018

Parenteral methotrexate does not perform better than placebo in preventing relapses of ulcerative colitis (UC) in patients who have achieved steroid-free response during induction therapy, a recent study has found.

A total of 179 patients with active UC (Mayo score 6–12 with endoscopy subscore ≥2) despite previous conventional or biological therapy were enrolled in a 48-week trial. All patients received subcutaneous methotrexate (25 mg/week) for 4 weeks, with a 12-week steroid taper (open-label phase). At week 16, steroid-free responders were randomly assigned to groups given either continued methotrexate (25 mg/week) or placebo until week 48 (maintenance phase).

Response occurred in 91 (51 percent) patients at week 16, and 84 patients were included in the maintenance phase (methotrexate group, n=44; placebo group, n=40). During this period, relapse of UC was reported in 29 methotrexate-treated patients vs 24 patients who received placebo (66 percent vs 60 percent; p=0.75).

At week 48, the number of patients who were in steroid-free clinical remission without need for additional therapies was likewise similar between the methotrexate and placebo groups (27 percent vs 30 percent; p=0.86).

There were no new safety signals detected for methotrexate.

Available therapeutic options for induction and maintenance of remission for patients with active UC are limited. The fact that biologics are costly highlight a need for affordable, easy to administer therapies such as methotrexate. However, while there is a dose–response relationship observed for methotrexate in the treatment of rheumatoid arthritis, more studies are needed to investigate methotrexate prospectively in studies using higher doses and employing parenteral administration (subcutaneous or intramuscular) in patients with UC. [Inflamm Bowel Dis 2010;16:1421-1430]

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Most Read Articles
06 Dec 2018
A strong belief in the necessity of medication is associated with better adherence to oral disease-modifying antirheumatic drugs (DMARDs) or prednisone, while higher self-efficacy correlates with poor adherence, in a diverse cohort of patients with rheumatoid arthritis (RA), suggests a study.
Pearl Toh, Yesterday
First-line therapy with the BTK* inhibitor ibrutinib plus the anti-CD20 immunotherapy rituximab confers significant survival advantage over the current gold-standard regimen of fludarabine, cyclophosphamide, and rituximab (FCR) for young, fit patients with treatment-naïve chronic lymphocytic leukaemia (CLL), according to the E1912 trial, a large cooperative group study supported by the US National Cancer Institute.
6 days ago
Low-dose administrations of haloperidol after thoracic surgery does not appear to prevent postoperative delirium, according to a new study.
4 days ago
Percutaneous coronary intervention (PCI) displays comparable rates of mortality and serious composite outcomes but a higher rate of target-vessel revascularization at 10 years relative to coronary artery bypass grafting (CABG) in patients with significant left main coronary artery (LMCA) disease, reports a study. On the other hand, CABG delivers lower mortality and serious composite outcome rates compared with PCI with drug-eluting stents after 5 years.