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Methotrexate does not increase cirrhosis risk in psoriatic patients with chronic viral hepatitis

26 Sep 2018

Long-term methotrexate (MTX) use in psoriatic patients with chronic viral hepatitis does not appear to increase the risk of liver cirrhosis, a recent study has found.

Accessing the National Health Insurance Research Database of Taiwan, researchers enrolled 2,417 psoriatic patients with chronic hepatitis B (CHB). Of them, 370 were on MTX (mean age 42.6±13.2 years; 72 percent male) while 2,047 were not (mean age 42.1±14.5 years; 70 percent male). A parallel group of 1,127 chronic hepatitis C patients (CHC) were enrolled, of whom 174 were MTX users (mean age 50.4±12.6 years; 64 percent male) while 953 were not (54.5±14.0 years; 61 percent male).

Multivariate Cox proportional hazards analysis revealed that older age at hepatitis diagnosis was associated with a higher risk of liver cirrhosis both in CHC (adjusted hazard ratio [HR], 1.03; 95 percent CI, 1.02–1.05; p<0.001) and CHB (adjusted HR, 1.04; 1.03–1.05; p<0.001) participants.

Moreover, male CHB patients (adjusted HR, 1.85; 1.17–2.91; p<0.05) and those prescribed with hepatitis B virus medication (adjusted HR, 8.16; 5.96–11.7), as well as CHC patients with comorbid diabetes mellitus (adjusted HR, 1.64; 1.05–2.57; p<0.05), were at elevated risk of liver cirrhosis.

In both patient groups, longer intervals between the diagnosis of psoriasis and chronic viral hepatitis progressively and significantly reduced the risk of liver cirrhosis.

Concomitant use of MTX was not associated with significant cirrhosis risk in either the CHB (adjusted HR, 0.72; 0.42–1.25) or CHC (adjusted HR, 0.96; 0.58–1.57) groups.

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Most Read Articles
Jairia Dela Cruz, 6 days ago
Use of standard-dose aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs) appears to confer protection against the risk of endometrial cancer in overweight and obese women, according to a meta-analysis.
Tristan Manalac, 6 days ago
Less than 15 percent of Singaporean adolescents get the recommended 8–10 hours of sleep on a school night, reports a recent study, noting that such short sleep duration is linked to symptoms of depression, overweight or obesity, and poorer self-rated health.
04 Jan 2019
Obstructive sleep apnoea may increase the risk of male-pattern baldness in men with a family history of hair loss, and this association appears to be mediated by low serum transferrin saturation levels related to hypoxia, a study suggests.
6 days ago
Airway type 2 inflammation remains persistent in many asthmatics on inhaled corticosteroids, a new study has shown. These patients tend to be older and have a more severe disease.