Most Read Articles
Roshini Claire Anthony, Yesterday

Many pregnant women may not be getting adequate nutrition as advised by dietary guidelines, researchers of an Australian study found.

6 days ago
The types of bariatric surgery differentially affect the risk of developing acute pancreatitis postoperatively, such that the risk is greater in patients who undergo vertical sleeve gastrectomy vs Roux-en-Y gastric bypass surgery, according to a study. Risk factors include younger age and presence of gallstones.
4 days ago
Misoprostol promotes the healing of small bowel ulcers in aspirin users whose condition is complicated by small bowel bleeding, reports a recent trial.
Jairia Dela Cruz, 5 days ago
An adjuvant trastuzumab treatment course shortened to 9 weeks has failed to demonstrate noninferiority to the standard 1-year course in terms of disease-free survival in breast cancer patients, although the shortened course confers benefits for the risk of severe cardiac toxicity, according to the results of the phase III randomized Short-HER study.

Methotrexate does not increase cirrhosis risk in psoriatic patients with chronic viral hepatitis

26 Sep 2018

Long-term methotrexate (MTX) use in psoriatic patients with chronic viral hepatitis does not appear to increase the risk of liver cirrhosis, a recent study has found.

Accessing the National Health Insurance Research Database of Taiwan, researchers enrolled 2,417 psoriatic patients with chronic hepatitis B (CHB). Of them, 370 were on MTX (mean age 42.6±13.2 years; 72 percent male) while 2,047 were not (mean age 42.1±14.5 years; 70 percent male). A parallel group of 1,127 chronic hepatitis C patients (CHC) were enrolled, of whom 174 were MTX users (mean age 50.4±12.6 years; 64 percent male) while 953 were not (54.5±14.0 years; 61 percent male).

Multivariate Cox proportional hazards analysis revealed that older age at hepatitis diagnosis was associated with a higher risk of liver cirrhosis both in CHC (adjusted hazard ratio [HR], 1.03; 95 percent CI, 1.02–1.05; p<0.001) and CHB (adjusted HR, 1.04; 1.03–1.05; p<0.001) participants.

Moreover, male CHB patients (adjusted HR, 1.85; 1.17–2.91; p<0.05) and those prescribed with hepatitis B virus medication (adjusted HR, 8.16; 5.96–11.7), as well as CHC patients with comorbid diabetes mellitus (adjusted HR, 1.64; 1.05–2.57; p<0.05), were at elevated risk of liver cirrhosis.

In both patient groups, longer intervals between the diagnosis of psoriasis and chronic viral hepatitis progressively and significantly reduced the risk of liver cirrhosis.

Concomitant use of MTX was not associated with significant cirrhosis risk in either the CHB (adjusted HR, 0.72; 0.42–1.25) or CHC (adjusted HR, 0.96; 0.58–1.57) groups.

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Most Read Articles
Roshini Claire Anthony, Yesterday

Many pregnant women may not be getting adequate nutrition as advised by dietary guidelines, researchers of an Australian study found.

6 days ago
The types of bariatric surgery differentially affect the risk of developing acute pancreatitis postoperatively, such that the risk is greater in patients who undergo vertical sleeve gastrectomy vs Roux-en-Y gastric bypass surgery, according to a study. Risk factors include younger age and presence of gallstones.
4 days ago
Misoprostol promotes the healing of small bowel ulcers in aspirin users whose condition is complicated by small bowel bleeding, reports a recent trial.
Jairia Dela Cruz, 5 days ago
An adjuvant trastuzumab treatment course shortened to 9 weeks has failed to demonstrate noninferiority to the standard 1-year course in terms of disease-free survival in breast cancer patients, although the shortened course confers benefits for the risk of severe cardiac toxicity, according to the results of the phase III randomized Short-HER study.