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Metformin prevents excessive weight gain in obese women with gestational diabetes

18 Dec 2019

Overweight or obese women with gestational diabetes mellitus (GDM) may fare well with metformin treatment, which is reported in a recent study to safely and effectively prevent excessive and promote adequate gestational weight gain (GWG) independent of age, body mass index (BMI) and timing of GDM diagnosis, among others.

The retrospective study included 457 pregnant women with GDM and pregestational overweight or obesity, among whom 177 (38.7 percent) were treated with metformin. Treated women received the drug from a mean of 28 weeks of gestation until delivery at a mean dose of 2,100 g/day.

Treated vs untreated women had higher pregestational weight (mean, 86.1 vs 78.5 kg; p<0.001) and BMI (mean, 32.67 vs 30.10 kg/m2; p<0.001), and more often presented with obesity grades 2 (20.9 percent vs 7.5 percent; p<0.001) and 3 (9.0 percent vs 3.9 percent; p<0.001).

In a propensity-matched analysis of 130 metformin-treated and 130 untreated patients, metformin was associated with significantly less excessive GWG (29.23 percent vs 42.31 percent; odds ratio [OR], 0.56, 95 percent confidence interval [CI], 0.34–0.94; p=0.028) and more adequate GWG (36.92 percent vs 23.08 percent; OR, 1.95, 95 percent CI, 1.14–3.35; p=0.015).

There were no significant between-group differences observed in terms of glycaemic control, rate of insulinization, and obstetric, foetal and neonatal outcomes.

The findings indicate that metformin may play an important role in the management of excessive GWG in overweight or obese women with GDM, according to the researchers.

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Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Jairia Dela Cruz, 3 days ago
Spending too much time sitting cannot be good for the body, and rising to one's feet breaks up such a behaviour and yields small, but meaningful, reductions in certain cardiovascular disease (CVD) risk factors, according to the results of a meta-analysis.
3 days ago
Use of thyroid hormone therapy does not seem to protect older adults with subclinical hypothyroidism against mortality, but it appears to confer survival benefits to those aged <65 years, results of a study have shown.