Most Read Articles
02 Sep 2018
The combination of maternal pregestational diabetes mellitus plus severe obesity is associated with a heightened risk of several psychiatric and mild neurodevelopmental disorders in offspring compared with either obesity or diabetes alone, a study suggests.
Rachel Soon, 30 Nov 2017

A care management program conducted via telephone for caregivers of patients with Alzheimer’s and other forms of dementia is associated with improved outcomes for both patients and carers, according to a new study in the United States.

07 Sep 2018
Individuals with attention deficiency hyperactivity disorder (ADHD) or anxiety are at greater risk of developing bipolar disorder, according to a study. Moreover, the risk further increases in those who have received diagnoses of both ADHD and anxiety.
Roshini Claire Anthony, 06 Apr 2016
A diagnosis of depression increases the risk of mortality and hospital readmission due to myocardial infarction (MI) in patients with stable coronary artery disease (CAD), according to a Canadian study presented at the recent American College of Cardiology’s 65th Annual Scientific Session in Chicago, Illinois, US.

Metabolic syndrome worsens elderly depression

13 Jan 2018

In elderly adults with depression, the presence of metabolic syndrome (MetS) appears to increase symptom severity and disorder chronicity, a recent study has found.

In 435 elderly adults receiving an open-label, protocolized extended-release venlafaxine treatment, the unadjusted model showed a significantly longer time to remission in participants with baseline MetS (n=222) than in those without (n=211; hazard ratio [HR], 0.71; 95 percent CI; 0.52–0.95; p=0.02).

After adjusting for potential confounders, such as gender and depressive episodes, the significant relationships (HR, 0.86; 0.64–1.16) were attenuated

In terms of individual metabolic variables, a higher diastolic blood pressure (DBP; HR, 0.88 per 10 mm Hg increase; 0.77–0.995) and the presence of more MetS components (HR, 0.89 per additional component; 0.80–0.99) were associated with shorter time to remission, according to a univariate regression model.

In contrast, elevated high-density lipoprotein cholesterol (HDL-C) levels predicted shorter time to remission (HR, 1.11 per 10 mg/dL increase; 1.02–1.21). Only DBP remained significantly predictive in the adjusted model (HR, 0.87 per 10 mm Hg increase; 0.77–0.99).

A history of smoking (p=0.81), cerebrovascular disease (p=0.95) and cardiovascular disease (p=0.95), insulin levels (p=0.88), HDL-C (p=0.46), and total cholesterol (p=0.79) had no significant effects on the time to remission.

Finally, the use of medications for glucose, lipids and blood pressure, such as coprescribed beta-blockers or antihypertensives, did not significantly change the relationships between the metabolic and atherosclerotic variables and time to remission.

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Most Read Articles
02 Sep 2018
The combination of maternal pregestational diabetes mellitus plus severe obesity is associated with a heightened risk of several psychiatric and mild neurodevelopmental disorders in offspring compared with either obesity or diabetes alone, a study suggests.
Rachel Soon, 30 Nov 2017

A care management program conducted via telephone for caregivers of patients with Alzheimer’s and other forms of dementia is associated with improved outcomes for both patients and carers, according to a new study in the United States.

07 Sep 2018
Individuals with attention deficiency hyperactivity disorder (ADHD) or anxiety are at greater risk of developing bipolar disorder, according to a study. Moreover, the risk further increases in those who have received diagnoses of both ADHD and anxiety.
Roshini Claire Anthony, 06 Apr 2016
A diagnosis of depression increases the risk of mortality and hospital readmission due to myocardial infarction (MI) in patients with stable coronary artery disease (CAD), according to a Canadian study presented at the recent American College of Cardiology’s 65th Annual Scientific Session in Chicago, Illinois, US.