Most Read Articles
Christina Lau, 23 Nov 2018

Use of a ginkgo biloba extract on top of standard preventive treatment is shown to improve cognitive function and overall condition after acute ischaemic stroke.

Metabolic syndrome worsens elderly depression

13 Jan 2018

In elderly adults with depression, the presence of metabolic syndrome (MetS) appears to increase symptom severity and disorder chronicity, a recent study has found.

In 435 elderly adults receiving an open-label, protocolized extended-release venlafaxine treatment, the unadjusted model showed a significantly longer time to remission in participants with baseline MetS (n=222) than in those without (n=211; hazard ratio [HR], 0.71; 95 percent CI; 0.52–0.95; p=0.02).

After adjusting for potential confounders, such as gender and depressive episodes, the significant relationships (HR, 0.86; 0.64–1.16) were attenuated

In terms of individual metabolic variables, a higher diastolic blood pressure (DBP; HR, 0.88 per 10 mm Hg increase; 0.77–0.995) and the presence of more MetS components (HR, 0.89 per additional component; 0.80–0.99) were associated with shorter time to remission, according to a univariate regression model.

In contrast, elevated high-density lipoprotein cholesterol (HDL-C) levels predicted shorter time to remission (HR, 1.11 per 10 mg/dL increase; 1.02–1.21). Only DBP remained significantly predictive in the adjusted model (HR, 0.87 per 10 mm Hg increase; 0.77–0.99).

A history of smoking (p=0.81), cerebrovascular disease (p=0.95) and cardiovascular disease (p=0.95), insulin levels (p=0.88), HDL-C (p=0.46), and total cholesterol (p=0.79) had no significant effects on the time to remission.

Finally, the use of medications for glucose, lipids and blood pressure, such as coprescribed beta-blockers or antihypertensives, did not significantly change the relationships between the metabolic and atherosclerotic variables and time to remission.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Psychiatry - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Christina Lau, 23 Nov 2018

Use of a ginkgo biloba extract on top of standard preventive treatment is shown to improve cognitive function and overall condition after acute ischaemic stroke.