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Metabolic syndrome worsens elderly depression

13 Jan 2018

In elderly adults with depression, the presence of metabolic syndrome (MetS) appears to increase symptom severity and disorder chronicity, a recent study has found.

In 435 elderly adults receiving an open-label, protocolized extended-release venlafaxine treatment, the unadjusted model showed a significantly longer time to remission in participants with baseline MetS (n=222) than in those without (n=211; hazard ratio [HR], 0.71; 95 percent CI; 0.52–0.95; p=0.02).

After adjusting for potential confounders, such as gender and depressive episodes, the significant relationships (HR, 0.86; 0.64–1.16) were attenuated

In terms of individual metabolic variables, a higher diastolic blood pressure (DBP; HR, 0.88 per 10 mm Hg increase; 0.77–0.995) and the presence of more MetS components (HR, 0.89 per additional component; 0.80–0.99) were associated with shorter time to remission, according to a univariate regression model.

In contrast, elevated high-density lipoprotein cholesterol (HDL-C) levels predicted shorter time to remission (HR, 1.11 per 10 mg/dL increase; 1.02–1.21). Only DBP remained significantly predictive in the adjusted model (HR, 0.87 per 10 mm Hg increase; 0.77–0.99).

A history of smoking (p=0.81), cerebrovascular disease (p=0.95) and cardiovascular disease (p=0.95), insulin levels (p=0.88), HDL-C (p=0.46), and total cholesterol (p=0.79) had no significant effects on the time to remission.

Finally, the use of medications for glucose, lipids and blood pressure, such as coprescribed beta-blockers or antihypertensives, did not significantly change the relationships between the metabolic and atherosclerotic variables and time to remission.

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Most Read Articles
Jairia Dela Cruz, 01 Jun 2018
Patients with congenital heart disease are more likely to develop dementia, particularly early-onset dementia, as compared with the general population, according to a study from Denmark.
Stephen Padilla, 01 Jun 2018
Long-term use of antidepressants, particularly during the second and third years of treatment, may lead to increases in body weight, a recent study has found.
01 Jun 2018
A 12-week circuit-training exercise intervention is a safe and feasible adjunct treatment in patients with first-episode psychosis, with potential benefits to certain domains of cognitive functioning especially in females, a study has shown.
31 May 2018
The levels of suicidal ideation are low and comparable among women who underwent vs were denied abortion, according to a recent US study.