Most Read Articles
12 Jun 2018
Percutaneous coronary intervention (PCI) is a safe procedure to perform on obese and morbidly obese patients, a recent study has shown.
Roshini Claire Anthony, 11 Jun 2018

Patients who received a combination of ticagrelor plus aspirin within 24 hours of undergoing coronary artery bypass grafting (CABG) had significantly improved saphenous vein graft patency rates 1 year post-procedure compared with those who only received aspirin, according to findings of the DACAB* trial.

4 days ago
Higher activity of plasma xanthine oxidase appears to be linked to insulin resistance and liver dysfunction among type 2 diabetes mellitus (T2DM) patients with metabolic syndrome (MetS), according to a recent Japan study.
4 days ago
Use of quetiapine among critically ill patients rarely leads to corrected QT (QTc) interval prolongation, reports a new study.

Metabolic syndrome worsens elderly depression

13 Jan 2018

In elderly adults with depression, the presence of metabolic syndrome (MetS) appears to increase symptom severity and disorder chronicity, a recent study has found.

In 435 elderly adults receiving an open-label, protocolized extended-release venlafaxine treatment, the unadjusted model showed a significantly longer time to remission in participants with baseline MetS (n=222) than in those without (n=211; hazard ratio [HR], 0.71; 95 percent CI; 0.52–0.95; p=0.02).

After adjusting for potential confounders, such as gender and depressive episodes, the significant relationships (HR, 0.86; 0.64–1.16) were attenuated

In terms of individual metabolic variables, a higher diastolic blood pressure (DBP; HR, 0.88 per 10 mm Hg increase; 0.77–0.995) and the presence of more MetS components (HR, 0.89 per additional component; 0.80–0.99) were associated with shorter time to remission, according to a univariate regression model.

In contrast, elevated high-density lipoprotein cholesterol (HDL-C) levels predicted shorter time to remission (HR, 1.11 per 10 mg/dL increase; 1.02–1.21). Only DBP remained significantly predictive in the adjusted model (HR, 0.87 per 10 mm Hg increase; 0.77–0.99).

A history of smoking (p=0.81), cerebrovascular disease (p=0.95) and cardiovascular disease (p=0.95), insulin levels (p=0.88), HDL-C (p=0.46), and total cholesterol (p=0.79) had no significant effects on the time to remission.

Finally, the use of medications for glucose, lipids and blood pressure, such as coprescribed beta-blockers or antihypertensives, did not significantly change the relationships between the metabolic and atherosclerotic variables and time to remission.

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Most Read Articles
12 Jun 2018
Percutaneous coronary intervention (PCI) is a safe procedure to perform on obese and morbidly obese patients, a recent study has shown.
Roshini Claire Anthony, 11 Jun 2018

Patients who received a combination of ticagrelor plus aspirin within 24 hours of undergoing coronary artery bypass grafting (CABG) had significantly improved saphenous vein graft patency rates 1 year post-procedure compared with those who only received aspirin, according to findings of the DACAB* trial.

4 days ago
Higher activity of plasma xanthine oxidase appears to be linked to insulin resistance and liver dysfunction among type 2 diabetes mellitus (T2DM) patients with metabolic syndrome (MetS), according to a recent Japan study.
4 days ago
Use of quetiapine among critically ill patients rarely leads to corrected QT (QTc) interval prolongation, reports a new study.