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Metabolic syndrome uncommon in centenarians

11 Jul 2018
Looking into 2018, Singapore has a few plans in mind to improve healthcare for the public, especially the elderly.

Metabolic syndrome (MetS) and its risk factors appear to be relatively uncommon in centenarians, which may potentially explain longevity, a recent China study has found.

Drawing data from home interviews and physical examinations, researchers examined the prevalence of MetS and associated risk factors in 874 centenarians (median age 102 years; 18.9 percent male). Venous blood samples collected from the participants were subjected to laboratory testing for the evaluation of serum concentrations of fasting blood glucose, total cholesterol and other markers.

Aside from MetS prevalence, researchers also assessed the correlation of the condition and associated risk factors with renal function using multivariate linear regression.

MetS was reported only in 136 participants, yielding an overall prevalence rate of 15.6 percent. In comparison, MetS risk factors were more common. For instance, majority (73.8 percent) of the participants presented with hypertension while 39.9 percent had dyslipidaemia. Abdominal obesity and diabetes mellitus were reported in 26.2 percent and 10.5 percent, respectively.

Regression analysis showed that of the MetS risk factors, smoking (β=3.980; p=0.002), abdominal obesity (β=1.566; p=0.005) and hypertension (β=1.396; p=0.040) were significantly correlated with glomerular filtration rate.

Other significant factors were age (β=–0.071; p=0.034), waist circumference (β=–0.193; p<0.001), and systolic (β=–0.086; p=0.036) and diastolic (β=0.132; p=0.001) blood pressure.

“Low prevalence of MetS and its risk factors was a possible reason of longevity, and the interrelationship of age, Mets and its risk factors with renal function was a possible mechanism of longevity in Chinese centenarians,” said researchers.

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Most Read Articles
Roshini Claire Anthony, 3 days ago

Patients with mild hypertension who are at low risk for cardiovascular disease (CVD) do not appear to derive mortality or CVD benefit from antihypertensive treatments, raising questions on the need for treatment in this population, according to a recent study from England.

Pearl Toh, 6 days ago
A personalized computerized neurofeedback intervention for training attention and memory shows potential in cognitive training for healthy elderly men, who improved in cognitive performance after the training, although no significant improvements were seen in the overall study population.
4 days ago
The simple Atrial fibrillation (AF) Better Care (ABC) pathway holistically updates the integrated care for AF patients and helps reduce the risk of adverse outcomes such as all-cause mortality, stroke/major bleeding/cardiovascular death and hospitalization, according to a study.
Yesterday
Type 1 diabetes impairs cognitive functioning in children, and this effect is exacerbated by extreme glycaemic levels, according to a recent meta-analysis.