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Metabolic syndrome uncommon in centenarians

11 Jul 2018
Looking into 2018, Singapore has a few plans in mind to improve healthcare for the public, especially the elderly.

Metabolic syndrome (MetS) and its risk factors appear to be relatively uncommon in centenarians, which may potentially explain longevity, a recent China study has found.

Drawing data from home interviews and physical examinations, researchers examined the prevalence of MetS and associated risk factors in 874 centenarians (median age 102 years; 18.9 percent male). Venous blood samples collected from the participants were subjected to laboratory testing for the evaluation of serum concentrations of fasting blood glucose, total cholesterol and other markers.

Aside from MetS prevalence, researchers also assessed the correlation of the condition and associated risk factors with renal function using multivariate linear regression.

MetS was reported only in 136 participants, yielding an overall prevalence rate of 15.6 percent. In comparison, MetS risk factors were more common. For instance, majority (73.8 percent) of the participants presented with hypertension while 39.9 percent had dyslipidaemia. Abdominal obesity and diabetes mellitus were reported in 26.2 percent and 10.5 percent, respectively.

Regression analysis showed that of the MetS risk factors, smoking (β=3.980; p=0.002), abdominal obesity (β=1.566; p=0.005) and hypertension (β=1.396; p=0.040) were significantly correlated with glomerular filtration rate.

Other significant factors were age (β=–0.071; p=0.034), waist circumference (β=–0.193; p<0.001), and systolic (β=–0.086; p=0.036) and diastolic (β=0.132; p=0.001) blood pressure.

“Low prevalence of MetS and its risk factors was a possible reason of longevity, and the interrelationship of age, Mets and its risk factors with renal function was a possible mechanism of longevity in Chinese centenarians,” said researchers.

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Most Read Articles
3 days ago
Prenatal and postpartum vitamin D supplementation does not appear to improve foetal or infant growth, a study reports.
5 days ago
Excessive daytime sleepiness appears to increase the long-term risk of amyloid β (Aβ) deposition, a recent study has shown.
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Substituting diets high in carbohydrates with those high in monounsaturated fatty acids in the context of low saturated fatty acids do not appear to yield favourable effects on blood pressure, according to a meta-analysis.
6 days ago
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