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Metabolic syndrome uncommon in centenarians

11 Jul 2018
Looking into 2018, Singapore has a few plans in mind to improve healthcare for the public, especially the elderly.

Metabolic syndrome (MetS) and its risk factors appear to be relatively uncommon in centenarians, which may potentially explain longevity, a recent China study has found.

Drawing data from home interviews and physical examinations, researchers examined the prevalence of MetS and associated risk factors in 874 centenarians (median age 102 years; 18.9 percent male). Venous blood samples collected from the participants were subjected to laboratory testing for the evaluation of serum concentrations of fasting blood glucose, total cholesterol and other markers.

Aside from MetS prevalence, researchers also assessed the correlation of the condition and associated risk factors with renal function using multivariate linear regression.

MetS was reported only in 136 participants, yielding an overall prevalence rate of 15.6 percent. In comparison, MetS risk factors were more common. For instance, majority (73.8 percent) of the participants presented with hypertension while 39.9 percent had dyslipidaemia. Abdominal obesity and diabetes mellitus were reported in 26.2 percent and 10.5 percent, respectively.

Regression analysis showed that of the MetS risk factors, smoking (β=3.980; p=0.002), abdominal obesity (β=1.566; p=0.005) and hypertension (β=1.396; p=0.040) were significantly correlated with glomerular filtration rate.

Other significant factors were age (β=–0.071; p=0.034), waist circumference (β=–0.193; p<0.001), and systolic (β=–0.086; p=0.036) and diastolic (β=0.132; p=0.001) blood pressure.

“Low prevalence of MetS and its risk factors was a possible reason of longevity, and the interrelationship of age, Mets and its risk factors with renal function was a possible mechanism of longevity in Chinese centenarians,” said researchers.

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Most Read Articles
4 days ago
Chocolate consumption is not associated with risk of coronary heart disease (CHD), stroke or both combined in postmenopausal women free of pre-existing major chronic disease, a study suggests.
Pearl Toh, 5 days ago
More intensive lowering of LDL-C levels was associated with a progressively greater survival benefit than less intensive approach, when the baseline LDL-C levels were ≥100 mg/dL, reveals a meta-analysis of 34 randomized trials.
4 days ago
Switching from thiazide diuretic to ipragliflozin, a sodium-glucose co-transporter 2 (SGLT2) inhibitor, leads to improvements in metabolic parameters and body mass composition without affecting blood pressure in type 2 diabetes (T2D) patients, a recent study has found.
2 days ago
Adolescents who sleep longer and have higher sleep efficiency have a favourable cardiometabolic profile, including lower abdominal adiposity, lower systolic blood pressure and higher high-density lipoprotein cholesterol levels, as shown in a study.