Metabolic syndrome implicated in hidradenitis suppurativa
Hidradenitis suppurativa (HS) carries about a twofold increased likelihood of having metabolic syndrome, according to the results of a meta-analysis.
Researchers searched multiple online databases for studies comparing patients with HS vs non-HS controls. All studies must have included either the number of patients with metabolic syndrome in each group or the magnitude of association between HS and metabolic syndrome.
The meta-analysis included six case–control studies, all of which had moderate level of evidence, with total scores on the Newcastle-Ottawa scale ranging between 6 and 7 out of 9.
Pooled data revealed metabolic syndrome to be significantly more common in the HS group than in the control group (odds ratio [OR], 1.95, 95 percent CI, 1.31–2.89; p=0.001; I2, 81 percent). The association between HS and metabolic syndrome persisted even after controlling for age, sex, other cardiovascular risk factors and comorbidities (OR, 2.19, 1.70–2.81; p<0.00001; I2, 32 percent).
While it remains to be established whether there exists a causal relationship—whether the chronic inflammatory nature of HS can trigger development of metabolic syndrome or whether associated features of metabolic syndrome predispose patients to develop HS—the researchers postulated that metabolic syndrome-related obesity may predispose to HS via follicular occlusion and the significantly higher amount of adipose cells, which produce inflammatory cytokines.
Nevertheless, the researchers stressed that clinicians managing patients with HS should be aware of the condition’s potential association with metabolic syndrome.