Most Read Articles
28 Apr 2018
Treatment with teriparatide increases periostin secretion, but it is unclear whether such increase facilitates the effect of the drug on bone, reports a recent study.
Jairia Dela Cruz, 03 Apr 2018
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24 Apr 2018
A subclinical inflammatory state resulting from increased adiposity and metabolic dysfunction appears to contribute to breast cancer pathogenesis in Asian women, a Taiwan study has found.
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Dietary glycaemic index (GI) or glycaemic load (GL) does not appear to have any significant effect on serum concentrations of inflammatory cytokines, including high-sensitivity C-reactive protein (hs-CRP), leptin, interleukin 6 (IL-6) and tumour necrosis factor α (TNF-α) in adults, reports a new study.

Menopausal hormone therapy reduces total, visceral adiposity

13 May 2018

Use of menopausal hormone therapy (MHT) is associated with significant decreases in visceral adipose tissue (VAT), body mass index (BMI) and android fat mass, a recent study has found. In addition, MHT appears to confer no benefit for lean body mass (LBM), and the benefits are not maintained in past users, suggesting caution when therapy is discontinued.

This cross-sectional study included women of the OsteoLaus cohort (aged 50–80 years) who underwent dual energy X-ray absorptiometry (DXA) with body composition assessment. Women under oestrogen-modifying medications were excluded. A total of 1,053 participants were categorized into current users, past users and never users of MHT.

The primary outcome was VAT measured by DXA. The investigators also assessed subtotal and android fat mass, LBM, muscle strength (hand grip) and confounding factors (caloric intake, physical activity, biomarkers).

Age significantly differed among participants: never users < current users < past users. Current users had lower age-adjusted VAT than never users (p=0.03), and they also showed lower age-adjusted BMI (–0.9 kg/m2) and a trend for lower fat mass (–1.3 kg).

Moreover, current users prevented a 10-year gain of VAT (p<0.01) and subtotal and android fat mass (p<0.05). There was no difference in LBM or hand grip.

Past users, including for early MHT discontinuers, did not display any residual effect. No significant between-group difference was observed for the confounding factors, except for higher caloric intake in past users vs never users.

“After menopause, fat mass and VAT increase and nonbone LBM decreases,” according to the investigators.

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Most Read Articles
28 Apr 2018
Treatment with teriparatide increases periostin secretion, but it is unclear whether such increase facilitates the effect of the drug on bone, reports a recent study.
Jairia Dela Cruz, 03 Apr 2018
A small cohort study presented at the Royal College of Obstetricians & Gynaecologists (RCOG) World Congress 2018 has reported a 5-year diabetic ketoacidosis (DKA) incidence rate of 4.16 percent in pregnant women with type 1 diabetes mellitus (T1DM), with generally good maternal and neonatal outcomes.
24 Apr 2018
A subclinical inflammatory state resulting from increased adiposity and metabolic dysfunction appears to contribute to breast cancer pathogenesis in Asian women, a Taiwan study has found.
25 Apr 2018
Dietary glycaemic index (GI) or glycaemic load (GL) does not appear to have any significant effect on serum concentrations of inflammatory cytokines, including high-sensitivity C-reactive protein (hs-CRP), leptin, interleukin 6 (IL-6) and tumour necrosis factor α (TNF-α) in adults, reports a new study.