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Tristan Manalac, 20 Dec 2018
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Memantine shows therapeutic potential in ADHD

02 Feb 2019

Use of memantine in the treatment of adults with attention deficit hyperactivity disorder (ADHD) appears to reduce symptoms associated with the condition, in addition to having a tolerable safety profile, a study has shown.

The study randomized 40 patients aged 18–45 years with ADHD to receive memantine (n=20; mean age 34.7 years) or placebo (mean age 31.5 years) for 6 weeks. Treatment was administered at 10 mg/day in the first week and then 20 mg/day thereafter. All patients completed the Conners' screening questionnaire.

Results showed significant differences in behaviour and attention deficit between the two groups after 6 weeks of treatment (p<0.001). Compared with placebo, memantine produced improvements from baseline in the following symptoms: inattention/memory problems, hyperactivity/restlessness and impulsivity/emotional lability.

Moreover, the ADHD Index significantly decreased over the treatment course in the memantine group (from 56.4 at baseline to 43.9 at week 3 and 36.7 at week 6) but remained stable in the placebo group (from 59.3 at baseline to 57.2 at week 3 and 59.7 at week 6).

In terms of safety, memantine was tolerable, and side effects were mild in severity. Commonly reported adverse events included dizziness, confusion, constipation, back pain and sleepiness.

The findings suggest that memantine is safe and effective for treating ADHD, researchers said. However, further studies are needed to evaluate such effects.

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Most Read Articles
Tristan Manalac, 20 Dec 2018
Motor activity appears to play a central role in mood regulation, according to a recent study, which also reports that subjective energy is important in motor activity.
Dr. Joseph Delano Fule Robles, 30 Jan 2019

Five subtypes of insomnia disorder were identified by investigators from The Netherlands, addressing an unmet need to reduce the heterogeneity of insomnia disorder.

07 Sep 2018
Individuals with attention deficiency hyperactivity disorder (ADHD) or anxiety are at greater risk of developing bipolar disorder, according to a study. Moreover, the risk further increases in those who have received diagnoses of both ADHD and anxiety.
21 Nov 2018
Adults with bipolar disorder who had been maltreated as a child are more likely to have a medical illness than adults with unipolar depression who have had the same experience, according to a study.