Most Read Articles
Roshini Claire Anthony, 4 days ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.
3 days ago
Serum 25-hydroxyvitamin D (25[OH]D) levels are significantly lower among patients with active uveitis than those with inactive uveitis and local population-based estimates, reports a study. In addition, vitamin D supplementation may help reduce uveitis activity, while sun exposure confers a beneficial effect to those with vitamin D deficiency.
2 days ago
The timing of direct oral anticoagulants (DOACs) administration, either within 3 days or ≥4 days of stroke onset, in patients with nonvalvular atrial fibrillation (AF) does not alter the risk of adverse outcomes such as stroke or systemic embolism, major bleeding, and death, as shown in a recent study.

Medroxyprogesterone acetate tied to minimal side effects, lower testosterone levels in transwomen

12 Nov 2019

Use of the feminizing hormone therapy medroxyprogesterone acetate (MPA) results in minimal side effects, unchanged oestradiol levels and a decline in testosterone in a cohort of transwomen, a study has found.

“MPA is a widely used progestin in feminizing hormone therapy,” the investigators said. “However, the side effects and hormonal changes elicited by this drug have never been investigated in the transgender population.”

The incidence of self-reported effects among transwomen using MPA and this drug’s impact on hormonal and metabolic parameters were evaluated by retrospectively collecting data from 290 follow-up visits of transwomen treated at Rhode Island Hospital from January 2011 to July 2018 (mean duration of therapy, 3.4±1.7 years).

Participants were treated with oestradiol and spironolactone with (n=102) or without MPA (n=188). Apart from assessing the incidence of self-reported effects after MPA treatment, blood levels of oestradiol, testosterone and various laboratory parameters were also compared between MPA and non-MPA groups.

Mean weighted oestradiol level was similar between MPA and non-MPA groups (211±57 vs 210±31 pg/mL; t[274]=0.143; p=0.886). Mean weighted testosterone level was significantly lower among transwomen treated with MPA than those who did not receive MPA (79±18 vs 215±29 ng/dL; t[122]=32.4; p<0.001). Minimal changes were observed in other laboratory parameters.

Of the 39 patients treated with MPA, 26 reported improved breast development and 11 reported reduced facial hair. On the other hand, five patients reported having mood swings on MPA.

“Prospective studies are needed to confirm our findings,” the investigators said.

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Most Read Articles
Roshini Claire Anthony, 4 days ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.
3 days ago
Serum 25-hydroxyvitamin D (25[OH]D) levels are significantly lower among patients with active uveitis than those with inactive uveitis and local population-based estimates, reports a study. In addition, vitamin D supplementation may help reduce uveitis activity, while sun exposure confers a beneficial effect to those with vitamin D deficiency.
2 days ago
The timing of direct oral anticoagulants (DOACs) administration, either within 3 days or ≥4 days of stroke onset, in patients with nonvalvular atrial fibrillation (AF) does not alter the risk of adverse outcomes such as stroke or systemic embolism, major bleeding, and death, as shown in a recent study.