Medolev® (Carbidopa + Levodopa)

12 Oct 2020
Medolev 275                                                          Medolev 125




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[link to https://mims.com/philippines/drug/info/medolev%20125-medolev%20275]


Carbidopa + Levodopa (Medolev®) – Levodopa, precursor of dopamine, used as dopamine replacement agent for PD.1–3 It is also used to manage bradykinetic symptoms in PD and improve the quality of life of patients with idiopathic PD.3 Carbidopa, an analogue of levodopa, inhibits dopa decarboxylase (enzyme present in the central and peripheral tissue). It reduces adverse effects such as nausea and vomiting.4 Levodopa is usually combined with carbidopa to enhance bioavailability and diminish fluctuations in the plasma level.5 The combination of carbidopa and levodopa remains as the most effective drug in improving the symptoms and quality of life of patients with PD.6
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