Most Read Articles
14 Feb 2020
Chronic pancreatitis patients taking antioxidants (AO) supplementation show a sustained increase in blood levels of AO, but no additional benefit is seen on endocrine and exocrine functions, markers of fibrosis, oxidative stress (OS) and inflammation, nutritional status, pain, and quality of life (QOL) when compared with those on placebo, according to a study.
Roshini Claire Anthony, 12 Feb 2020

Children with inflammatory bowel disease (IBD) do not appear to have an elevated risk of lymphoma following treatment with anti-tumour necrosis factor (TNF) agents, according to a study presented at the recent Crohn’s and Colitis Congress 2020.

Jairia Dela Cruz, 2 days ago
A diet low in fat and high in fibre seems well tolerated in patients with ulcerative colitis, not contributing to increased inflammation while significantly increasing populations of Faecalibacterium prausnitzii, according to a study presented at the 2020 Crohn's & Colitis Congress.
Pearl Toh, 6 days ago
Donor selection for faecal microbiota transplant (FMT) can make a difference to maintenance of long-term remission in patients with ulcerative colitis (UC), reveals a study presented at the 2020 Crohn's & Colitis Congress (CCC).

Medication nonadherence may lead to treatment escalation in children with UC

03 Nov 2019

In paediatric patients with ulcerative colitis (UC), nonadherence to mesalazine negatively affects its therapeutic efficacy and may, in turn, result in treatment escalation, according to data from PROTECT.

PROTECT included 268 newly diagnosed paediatric UC patients (mean age, 12.3 years; 50 percent female). All patients received standardized mesalazine, with pre‐established criteria for escalation to thiopurines or anti‐tumour necrosis factor alpha (TNFα inhibitors). Adherence was monitored using pill bottles with electronic caps.

Researchers examined whether longitudinal adherence to treatment was associated with steroid‐free remission at week 52 (defined as quiescent disease on mesalazine alone with no corticosteroids ≥4 weeks prior) and need for treatment escalation (defined as introduction of immunomodulators, calcineurin‐inhibitors or anti‐TNFα inhibitors).

Results revealed that average mesalazine adherence trajectories were not predictive of steroid‐free remission at week 52. On the other hand, declining adherence over time (adherence rate of ≤85.7 percent at month 6) showed a strong association with treatment escalation (p=0.001).

According to the researchers, the present data highlight the importance of targeting adherence difficulties early in the disease course to reduce the likelihood of the need for treatment escalation in this population. They also stressed that treatment escalation is not based on suboptimal adherence to maintenance medication, but rather on disease response (or lack of response) to maintenance medication.

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Most Read Articles
14 Feb 2020
Chronic pancreatitis patients taking antioxidants (AO) supplementation show a sustained increase in blood levels of AO, but no additional benefit is seen on endocrine and exocrine functions, markers of fibrosis, oxidative stress (OS) and inflammation, nutritional status, pain, and quality of life (QOL) when compared with those on placebo, according to a study.
Roshini Claire Anthony, 12 Feb 2020

Children with inflammatory bowel disease (IBD) do not appear to have an elevated risk of lymphoma following treatment with anti-tumour necrosis factor (TNF) agents, according to a study presented at the recent Crohn’s and Colitis Congress 2020.

Jairia Dela Cruz, 2 days ago
A diet low in fat and high in fibre seems well tolerated in patients with ulcerative colitis, not contributing to increased inflammation while significantly increasing populations of Faecalibacterium prausnitzii, according to a study presented at the 2020 Crohn's & Colitis Congress.
Pearl Toh, 6 days ago
Donor selection for faecal microbiota transplant (FMT) can make a difference to maintenance of long-term remission in patients with ulcerative colitis (UC), reveals a study presented at the 2020 Crohn's & Colitis Congress (CCC).