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Medication administration causes feeding tube obstruction

07 Aug 2019

The combination of metformin, nystatin, linagliptin, rivaroxaban and a high-protein diet is the main cause of nasoenteral tube obstruction, with corresponding odds ratios of 2.0, 3.1, 4.3, 2.4 and 1.9, according to a recent study.

Of the 1,170 patients included in the analysis, 1,084 received enteral nutrition and medication through the feeding tube, and 86 received medication alone.

Obstruction rates were 4 percent and 8 percent for up to 40 days of observation and for the total observation time, respectively. The time for obstruction of 10 percent of the tubes was 16 days in rivaroxaban users, 19 days in linagliptin users, 20 days in metformin users and 28 days in nystatin users.

“Overall, proper tube care and strict compliance with tubal drug delivery guidelines can result in low tube obstruction rates,” the investigators said.

This retrospective cohort study included patients aged 18 years (median age, 79 years; 58 percent men) who were hospitalized at Sírio-Libanês Hospital in São Paulo, Brazil, between January 2015 and October 2017, and who were undergoing enteral nutrition therapy delivered using an infusion pump through a nasogastric or nasoenteral tube.

The following variables were investigated as potential causes of feeding tube obstruction: administration of medication through the tube, type of diet and use of symbiotics.

“Obstruction of the nasoenteral tube is one of the complications of enteral nutrition therapy, and its causes and frequency of occurrence are not well understood,” the investigators said.

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Most Read Articles
Roshini Claire Anthony, 09 Oct 2020

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Audrey Abella, 10 Sep 2020
Interim results of REGENERATE* trial highlight the ability of experimental noninvasive tests to evaluate treatment response in adults with NASH** and advanced liver fibrosis who are receiving obeticholic acid (OCA).
Rachel Soon, 28 Aug 2020
MOH Director-General Tan Sri Dato' Seri Dr Noor Hisham Abdullah speaks about NHMS 2019 and pharmacists' roles in combating NCDs among Malaysians.
Jairia Dela Cruz, 23 Sep 2020
The combination of pitavastatin and fenofibrate appears to have superior effect on non-high-density lipoprotein cholesterol (non–HDL-C), as well as other lipids, compared with a statin alone in high-risk patients with mixed dyslipidemia, according to a study.