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Medication administration causes feeding tube obstruction

07 Aug 2019

The combination of metformin, nystatin, linagliptin, rivaroxaban and a high-protein diet is the main cause of nasoenteral tube obstruction, with corresponding odds ratios of 2.0, 3.1, 4.3, 2.4 and 1.9, according to a recent study.

Of the 1,170 patients included in the analysis, 1,084 received enteral nutrition and medication through the feeding tube, and 86 received medication alone.

Obstruction rates were 4 percent and 8 percent for up to 40 days of observation and for the total observation time, respectively. The time for obstruction of 10 percent of the tubes was 16 days in rivaroxaban users, 19 days in linagliptin users, 20 days in metformin users and 28 days in nystatin users.

“Overall, proper tube care and strict compliance with tubal drug delivery guidelines can result in low tube obstruction rates,” the investigators said.

This retrospective cohort study included patients aged 18 years (median age, 79 years; 58 percent men) who were hospitalized at Sírio-Libanês Hospital in São Paulo, Brazil, between January 2015 and October 2017, and who were undergoing enteral nutrition therapy delivered using an infusion pump through a nasogastric or nasoenteral tube.

The following variables were investigated as potential causes of feeding tube obstruction: administration of medication through the tube, type of diet and use of symbiotics.

“Obstruction of the nasoenteral tube is one of the complications of enteral nutrition therapy, and its causes and frequency of occurrence are not well understood,” the investigators said.

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Jairia Dela Cruz, 12 Dec 2019
Use of isatuximab (Isa) in combination with pomalidomide and dexamethasone (PomDex) appears to lead to more favourable outcomes in elderly patients with relapsed/refractory multiple myeloma (RRMM) as compared with PomDex alone, according to the results of a subgroup analysis of the ICARIA-MM trial presented at the 61st Annual Meeting of the American Society of Hematology (ASH 2019).
Rachel Soon, 2 days ago

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Pearl Toh, 13 Oct 2018
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