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Maternal thyroid dysfunction ups risk of neurocognitive outcomes in offspring

20 Oct 2020

Thyroid dysfunction during pregnancy is associated with several neurocognitive outcomes in the offspring, suggest the results of a study. Prompt examination and treatment on thyroid function is urged for pregnant women.

“Previous studies suggested a potential link of maternal thyroid dysfunction with adverse neurocognitive outcomes and impaired development of internal organs in offspring,” the authors said.

A systematic review and meta-analysis was performed to assess the relationship between maternal thyroid dysfunction and the risk of adverse outcomes in the offspring, The authors searched the databases of PubMed, Embase and the Cochrane Library for studies reporting the association between maternal thyroid hormone function and the risk of adverse outcomes in their children.

Reviewers independently extracted data on study characteristics and results. The authors pooled and reported estimates as odds ratio (OR) with 95 percent confidence interval (CI). They also applied I2 tests to evaluate the heterogeneity across studies.

Twenty-nine studies met the eligibility criteria. Meta-analysis revealed the association of maternal hyperthyroidism with attention deficit hyperactivity disorder (ADHD; OR, 1.18, 95 percent CI, 1.04-1.34; I2, 0 percent) and epilepsy (OR, 1.19, 95 percent CI, 1.08–1.31; I2, 0 percent) in offspring.

In addition, maternal hypothyroidism correlated with an increased risk of ADHD (OR, 1.14, 95 percent CI, 1.03–1.26; I2, 25 percent), autism spectrum disorder (OR, 1.41, 95 percent CI, 1.05–1.90; I2, 63 percent), and epilepsy (OR, 1.21, 95 percent CI, 1.06–1.39; I2, 0 percent) in offspring.

“Routine measurement and timely treatment on thyroid function should be considered for pregnant women,” the authors said.

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Pearl Toh, 21 Nov 2020
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