Most Read Articles
Jairia Dela Cruz, 13 Oct 2016
Children born to obese mothers are at increased risk of developing autism spectrum disorder (ASD) compared with children born to normal-weight mothers, according to data from a review and meta-analysis.
Yap Te-Lu, Anette Sundfor Jacobsen, 01 Oct 2013

Antenatal hydronephrosis (ANH) is a general term used to describe the dilatation of the fetal renal pelvis and/or its calyces. In pelviectasis, there is only dilatation of the renal pelvis; while in caliectasis, there is dilatation of the calyces. ANH is the most commonly diagnosed congenital urinary tract anomaly, which is detected by prenatal screening in 1–5% of all pregnancies

Yap Te-Lu, Anette Sundfor Jacobsen, 01 Dec 2012

Antenatal hydronephrosis (ANH) is a general term used to describe the dilatation of the fetal renal pelvis and/or its calyces. In pelviectasis, there is only dilatation of the renal pelvis; while in caliectasis, there is dilatation of the calyces. ANH is the most commonly diagnosed congenital urinary tract anomaly, which is detected by prenatal screening in 1–5% of all pregnancies.

Yap Te-Lu, Anette Sundfor Jacobsen, 01 Apr 2011

Antenatal hydronephrosis (ANH) is a general term used to describe the dilatation of the fetal renal pelvis and/or its calyces. In pelviectasis, there is only dilatation of the renal pelvis; while in caliectasis, there is dilatation of the calyces. ANH is the most commonly diagnosed congenital urinary tract anomaly, which is detected by prenatal screening in 1–5% of all pregnancies.

Maternal smoking during pregnancy may increase infant mortality due to NEC

20 Apr 2017

Maternal smoking during pregnancy appears to contribute to an increase in the risk of necrotizing enterocolitis (NEC)-specific mortality in premature infants, especially those who are female and white, a study suggests.

The population-based cohort study included 1,315,493 eligible singletons, live preterm babies. There were 1,122 NEC-associated deaths (<1 year of age), with the majority (82.7 percent) occurring in the late neonatal period (7 to 27 days after birth), corresponding to a mortality rate of 8.5 per 10,000 live births.

Maternal smoking during pregnancy were classified into three categories: nonsmoking, light smoking (average of <10 cigarettes/day) and heavy smoking (average of ≥10 cigarettes/day). Logistic regression analyses, with adjustment for potential confounders, were performed to test the association between prenatal smoking and NEC-associated infant mortality rates

Compared with nonsmoking, light and heavy smoking during pregnancy increased the odds of NEC-associated infant mortality by 21 percent (95 percent CI, 1.03 to 1.43) and 30 percent (1.12 to 1.52), respectively. The effect of smoking on NEC-associated infant mortality was more pronounced among infants with white race (light smoking: adjusted odds ratio [aOR], 1.69; 1.34 to 2.13; heavy smoking: aOR, 1.44; 1.18 to 1.75) and female gender (light smoking: aOR, 1.31; 1.02 to 1.69; heavy smoking: aOR, 1.62; 1.29 to 2.02).

The current study demonstrates that maternal smoking, both light and heavy, during pregnancy may increase the risk of mortality in premature infants due to NEC. “[This] may have implications in basic and epidemiologic research on the mechanisms that underlie NEC-associated development and death.”

The most common gastrointestinal emergency in neonates, NEC is an important cause of morbidity and mortality in neonates, with the mortality rate of between 15 and 25 percent remaining stable in the last 30 years. Factors such as hypoxic-ischaemic injury, feeding with formula milk and colonization by pathological bacteria are generally considered to contribute to the development of NEC. The risk is further increased by prematurity and low birthweight due to developmental immaturity of key functions such as intestinal function, circulatory regulation and immune defense in these infants. [Lancet 2006;368:1271–1283; Annu Rev Med 2009;60:111–124; Neonatology 2009;96:203–10; Semin Fetal Neonatal Med 2011;16:145–150]

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Most Read Articles
Jairia Dela Cruz, 13 Oct 2016
Children born to obese mothers are at increased risk of developing autism spectrum disorder (ASD) compared with children born to normal-weight mothers, according to data from a review and meta-analysis.
Yap Te-Lu, Anette Sundfor Jacobsen, 01 Oct 2013

Antenatal hydronephrosis (ANH) is a general term used to describe the dilatation of the fetal renal pelvis and/or its calyces. In pelviectasis, there is only dilatation of the renal pelvis; while in caliectasis, there is dilatation of the calyces. ANH is the most commonly diagnosed congenital urinary tract anomaly, which is detected by prenatal screening in 1–5% of all pregnancies

Yap Te-Lu, Anette Sundfor Jacobsen, 01 Dec 2012

Antenatal hydronephrosis (ANH) is a general term used to describe the dilatation of the fetal renal pelvis and/or its calyces. In pelviectasis, there is only dilatation of the renal pelvis; while in caliectasis, there is dilatation of the calyces. ANH is the most commonly diagnosed congenital urinary tract anomaly, which is detected by prenatal screening in 1–5% of all pregnancies.

Yap Te-Lu, Anette Sundfor Jacobsen, 01 Apr 2011

Antenatal hydronephrosis (ANH) is a general term used to describe the dilatation of the fetal renal pelvis and/or its calyces. In pelviectasis, there is only dilatation of the renal pelvis; while in caliectasis, there is dilatation of the calyces. ANH is the most commonly diagnosed congenital urinary tract anomaly, which is detected by prenatal screening in 1–5% of all pregnancies.