Most Read Articles
Pearl Toh, 31 Dec 2019
Adding the neuraminidase inhibitor oseltamivir to usual care speeds up recovery from influenza-like illness by a day compared with usual care alone, with even greater benefits seen in older, sicker patients with comorbidities, according to the ALIC4E study.
Roshini Claire Anthony, 20 hours ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.
09 Jan 2020
Acute ischaemic stroke patients who are current or recent smokers are at greater odds of having unfavourable functional outcomes 3 months after the index event, a study has found.

Maternal PCOS tied to increased likelihood of having a child with autism

02 Jan 2020

Women with polycystic ovarian syndrome (PCOS) are at greater odds of having a child with autism spectrum disorder (ASD) and are more likely to be diagnosed with ASD themselves, according to the results of a meta-analysis.

Researchers searched multiple online databases for cohort (both prospective and retrospective), case–control or cross-sectional studies that reported ASD diagnosis in the offspring of women with PCOS or on ASD diagnosis in women with PCOS.

The meta-analysis included 10 studies involving 33,887 ASD children and 321,661 non-ASD children. Pooled data revealed that the primary outcome of odds of ASD in the offspring were 1.66 times as great for mothers who were diagnosed with PCOS (95 percent confidence interval [CI], 1.51–1.83; p=1.99 × 10−25; seven studies; I2, 0 percent).

Additionally, a PCOS diagnosis was associated with 1.78 times higher odds of having concomitant ASD (95 percent CI, 1.10–2.87; p=0.0179; five studies; I2, 85.4 percent). The results were robust to additional analyses controlling for potential confounding factors.

Overall evidence quality according to the Newcastle–Ottawa Scale was high. The pooled effects size had low heterogeneity for the primary outcome. On the other hand, the heterogeneity for the secondary outcome was attenuated when only high quality studies were included.

The researchers noted that a common gene polymorphism predisposing to PCOS and ASD is a plausible mechanism for the observed associations, given the apparently increased odds of an ASD diagnosis in both women with PCOS as well as their offspring.

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Most Read Articles
Pearl Toh, 31 Dec 2019
Adding the neuraminidase inhibitor oseltamivir to usual care speeds up recovery from influenza-like illness by a day compared with usual care alone, with even greater benefits seen in older, sicker patients with comorbidities, according to the ALIC4E study.
Roshini Claire Anthony, 20 hours ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.
09 Jan 2020
Acute ischaemic stroke patients who are current or recent smokers are at greater odds of having unfavourable functional outcomes 3 months after the index event, a study has found.