Maternal LUTS an independent risk factor of LUT dysfunction in children
Children born to mothers with lower urinary tract symptoms (LUTS) are highly likely to have LUT dysfunction, a study suggests.
The cross-sectional multicentre study included 827 mother-child pairs (mean age of mothers 35.9 years; mean age of children 9.1 years; 50.06 percent of children were male). Exclusion criteria for children included having neurological problems, previously detected urinary tract abnormalities or refusal to sign the informed consent or assent form.
Urinary symptoms were assessed using the dysfunctional voiding score symptom (DVSS) questionnaire in children and the Incontinence Questionnaire Overactive Bladder (ICIQ-OAB) questionnaire in mothers, whereas constipation in the children was evaluated using the ROME III criteria.
Of the children, 38.1 percent had urinary symptoms (occurring at least once or twice a week), 17 percent had urinary urgency, and 13.8 percent had incontinence. Of the mothers, 45.7 percent had at least one LUTS, 18.5 percent had urgency, and 12.5 percent had incontinence.
DVSS questionnaire data showed the overall prevalence of LUT dysfunction to be 9.1 percent, with the DVSS scores of children being significantly associated with the ICIQ-OAB scores of mothers (p<0.0010). Mothers with urinary symptoms were 2.5 (95 percent CI, 1.52 to 4.17) times as likely as those without the symptoms to have a child with LUT dysfunction (p<0.001), whereas mothers with overactive bladder were 2.8 (1.63 to 4.86) times as likely as those without the condition to have a child with an overactive bladder (p<0.001). Mothers with incontinence and urinary urgency also had a high likelihood of having children with the same conditions.
Multivariate analysis confirmed the presence of LUTS in mothers as an independent predictor of LUT dysfunction in children, in addition to factors including female sex, enuresis and constipation.
The current data show that the association between LUTS in mothers and LUT dysfunction in children may also be observed for overactive bladder, as well as the isolated symptoms of urinary urgency and incontinence.