Maternal influenza, tetanus toxoid vax not tied to infant hospitalizations, deaths
Maternal influenza and Tdap (tetanus toxoid, reduced diphtheria toxoid, acellular pertussis) vaccinations during pregnancy do not increase the risk for hospitalization or death in infants, a study has shown.
“We found no increased risk of infant all-cause hospitalizations, hospitalizations from respiratory causes, or all-cause mortality in the first 6 months of life,” said the researchers led by Dr Lakshmi Sukumaran from the Centers for Disease Control and Prevention in Atlanta, Georgia, US. Vaccination during pregnancy was defined in the study as a jab given from 7 days after the start of pregnancy to 7 days before the end of pregnancy.
Long-term data on infants born to mothers administered influenza and Tdap vaccines have been lacking. The current study was the first to look at infant hospitalizations and mortality in the first 6 months of life after influenza and Tdap vaccines administration in mothers.
Of 413,034 infants involved in the study, 25,222 were hospitalized (4,644 were due to a respiratory cause, 105 from influenza, 137 because of pertussis) during the first 6 months of life; 157 died from unknown causes, sudden infant death syndrome, or certain conditions originating in the perinatal period.
However, there was no association between infant hospitalization and maternal influenza vaccination (adjusted odds ratio [adjOR], 1.00, 95 percent confidence interval [CI], 0.96–1.04) or Tdap vaccination (adjOR, 0.94, 95 percent CI, 0.88–1.01). There was also no link between infant mortality and maternal influenza (adjOR, 0.96, 95 percent CI, 0.54–1.69) or Tdap (adjOR, 0.44, 95 percent CI, 0.17 - 1.13) vaccinations.
The researchers said the current study supports the safety of influenza and pertussis vaccinations during pregnancy for both the mothers and their babies.