Most Read Articles
6 days ago
Ivermectin confers benefits in the treatment of COVID-19, with a recent study showing that its use helps reduce the risk of death especially in patients with severe pulmonary involvement.
5 days ago
Mental health comorbidities are common among patients with type 2 diabetes mellitus and may lead to worse outcomes, a recent study has found.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

2 days ago
Vitamin D deficiency may be a contributing factor to the mortality rate among patients with the novel coronavirus disease (COVID-19), reports a new study.

Maternal infection during pregnancy contributes to childhood obesity

26 Apr 2020

Maternal infection, but not antibiotic use, during pregnancy bears a heightened risk of childhood obesity, a study suggests.

The analysis included 145,393 mother-child dyads, grouped into four comparison cohorts, as follows: (1) unexposed controls (no infection/no antibiotic use), (2) untreated infection (had infection, but received no antibiotics), (3) treated with infection (had infection and treated with antibiotics), and (4) treated without infection (received antibiotics without evidence of an infection during pregnancy, likely due to prophylactic treatment).

In an analysis controlling for confounders using propensity score methodology, maternal antibiotic use during pregnancy had null effect on the risk of childhood obesity once underlying infection was controlled for (odds ratio [OR], 0.97, 95 percent confidence interval [CI], 0.92–1.01). Likewise, there was no risk increase observed with timing of use or use of broad-spectrum antibiotics, nor a dose-response relationship.

On the other hand, maternal untreated infection (without antibiotic use) during pregnancy carried a significant increase in the risk of childhood obesity compared with unexposed control (OR, 1.09, 95 percent CI, 1.03–1.16). The association was more pronounced for group B streptococcal (GBS) positive infection (OR, 1.16) than GBS negative infections (OR, 1.08).

The results were consistent in a discordant sibling study, which allowed additional control of unmeasured confounders including genetic, maternal intrauterine and familiar factors.

In light of the findings, researchers emphasized that while use of antibiotics should always be judicious, maternal infections during pregnancy should be treated to prevent childhood obesity.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
6 days ago
Ivermectin confers benefits in the treatment of COVID-19, with a recent study showing that its use helps reduce the risk of death especially in patients with severe pulmonary involvement.
5 days ago
Mental health comorbidities are common among patients with type 2 diabetes mellitus and may lead to worse outcomes, a recent study has found.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

2 days ago
Vitamin D deficiency may be a contributing factor to the mortality rate among patients with the novel coronavirus disease (COVID-19), reports a new study.