Most Read Articles
11 May 2020
This second issue revisits the impact EMPA-REG OUTCOME had on clinical practice and helps readers discover how it gives life back to patients through its cardiovascular indication. Learn how it was approved and the possible mechanisms for its cardiovascular benefits.
Pearl Toh, 15 Oct 2020
Cycling was associated with reduced risk for both all-cause and cardiovascular (CV) mortality in people with diabetes, according to a study presented at EASD 2020 Meeting — suggesting that cycling could be encouraged as an activity to prevent deaths in this population who are known to have a higher mortality risk than the general public.
Stephen Padilla, 22 Jul 2019
Zinc supplementation significantly lowers key glycaemic indicators, particularly fasting glucose (FG) in individuals with diabetes and in those who received an inorganic supplement, results of a systematic review and meta-analysis have shown.
Elaine Soliven, 15 Oct 2020

Higher levels of exercise appear to be associated with a lower risk of all-cause mortality in adults with type 2 diabetes (T2D) compared with no exercise at all, according to a study presented at EASD 2020.

Maternal, paternal diabetes histories confer different degrees of risk to offspring

04 Aug 2020

Maternal and paternal histories of diabetes have different effects on offspring risk of insulin secretion and resistance, and diabetes, a new study has found.

Drawing from the China National Diabetes and Metabolism Disorders Study, researchers enrolled 39,244 participants and divided them into four, according to parental history: negative parental history (FH0; n=34,913), paternal history only (PH; n=1,628), maternal history only (MH; n=2,378), and both maternal and paternal history (FH2; n=325).

Insulin secretion capacity, as assessed by the homeostatic model assessment for β-cell function (HOMA-B) and the insulinogenic index, was best in the FH0 group and worst in the FH2 group. The insulinogenic index in the MH group was significantly lower than that in the PH group (13.54 vs 18.06; p=0.0434). The Matsuda index (ISIm), on the other hand, was higher in the MH group (7.58 vs 6.93; p=0.0276).

Diabetes, prediabetes, and impaired glucose metabolism were most prevalent in the FH2 group, while the FH0 group saw the lowest estimates. Impaired glucose metabolism was significantly more common in the MH vs PH group (31.13 percent vs 25.41 percent; p=0.0134); no such difference was reported for diabetes and prediabetes.

The risk of diabetes was significantly elevated in the PH group relative to the FH0 participants (odds ratio [OR], 2.01, 95 percent confidence interval [CI], 1.57–2.59; p<0.0001). The MH group also saw a significant spike in diabetes likelihood, albeit to a greater degree (OR, 2.67, 95 percent CI, 2.21–3.23; p<0.0001).

A similar trend was reported for impaired glucose metabolism. MH (OR, 1.65, 95 percent CI, 1.42–1.91; p<0.0001) had a stronger effect than PH (OR, 1.28, 95 percent CI, 1.06–1.54; p=0.009), though both emerged as significant risk factors.

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Most Read Articles
11 May 2020
This second issue revisits the impact EMPA-REG OUTCOME had on clinical practice and helps readers discover how it gives life back to patients through its cardiovascular indication. Learn how it was approved and the possible mechanisms for its cardiovascular benefits.
Pearl Toh, 15 Oct 2020
Cycling was associated with reduced risk for both all-cause and cardiovascular (CV) mortality in people with diabetes, according to a study presented at EASD 2020 Meeting — suggesting that cycling could be encouraged as an activity to prevent deaths in this population who are known to have a higher mortality risk than the general public.
Stephen Padilla, 22 Jul 2019
Zinc supplementation significantly lowers key glycaemic indicators, particularly fasting glucose (FG) in individuals with diabetes and in those who received an inorganic supplement, results of a systematic review and meta-analysis have shown.
Elaine Soliven, 15 Oct 2020

Higher levels of exercise appear to be associated with a lower risk of all-cause mortality in adults with type 2 diabetes (T2D) compared with no exercise at all, according to a study presented at EASD 2020.