Most Read Articles
Pearl Toh, 22 Oct 2020
The combination therapy comprising carfilzomib, cyclophosphamide and dexamethasone (KCd) is effective, with a tolerable safety profile, in an Asian cohort with high-risk multiple myeloma (MM) — thus providing a more economical alternative as a potential upfront regimen in resource-limited settings, according to leading experts during a myeloma education webinar.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

Pearl Toh, 6 days ago
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.
Elvira Manzano, 17 Nov 2020
Invasive fungal infections, particularly those caused by Candida species, are common in hospitalized, immunocompromised, or critically ill patients and are associated with considerable morbidity and mortality.

Mass eradication of H. pylori infection eliminates gastric cancer threat

02 Sep 2020

Population-based eradication of Helicobacter pylori infection leads to a marked reduction in gastric cancer incidence with no increase in the likelihood of adverse consequences, a study has found.

Researchers examined the benefits and potential risks of mass eradication of H. pylori infection launched in 2004 and lasted until 2018 in a high-risk Taiwanese population aged 30 years with prevalent infection. In the programme, individuals who tested positive for the 13C-urea breath test underwent eradication therapy.

Population-based registry revealed that the total number of residents grew from 9,359 in 2004 to 12,536 in 2016. After six rounds of mass screening and eradication, the overall coverage rate among target population of individuals aged 30 years arrived at 85.5 percent (6,512/7,616). Among those who tested positive for H. pylori, the overall referral rate for the antibiotic treatment was 93.5 percent (4,286/4,584).

The prevalence rates of H. pylori infection dropped from 64.2 percent to 15.0 percent, with meagre reinfection rates of <1 percent per person-year. A concurrent decline in the presence and severity of atrophic gastritis and intestinal metaplasia occurred over time.

Relative to the historical control period from 1995 to 2003, mass eradication of H. pylori during the prevention period led to a reduction of 53 percent (95 percent confidence interval [CI], 30–69; p<0.001) in gastric cancer incidence and of 25 percent (95 percent CI, −14 to 51; p=0.18) in mortality.

There were no significant changes observed in the incidence rates of other digestive tract cancers or the antibiotic resistance rate of H. pylori.

The present data suggest that the eradication programme will further lead to a significant reduction in mortality from gastric cancer and ultimately achieve the goal of eliminating the gastric cancer burden in the area, the researchers said.

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Most Read Articles
Pearl Toh, 22 Oct 2020
The combination therapy comprising carfilzomib, cyclophosphamide and dexamethasone (KCd) is effective, with a tolerable safety profile, in an Asian cohort with high-risk multiple myeloma (MM) — thus providing a more economical alternative as a potential upfront regimen in resource-limited settings, according to leading experts during a myeloma education webinar.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

Pearl Toh, 6 days ago
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.
Elvira Manzano, 17 Nov 2020
Invasive fungal infections, particularly those caused by Candida species, are common in hospitalized, immunocompromised, or critically ill patients and are associated with considerable morbidity and mortality.