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Market Watch - QV Intensive with Ceramides

01 Sep 2018

QV Intensive with Ceramides
Ego Pharm Malaysia Sdn Bhd

A scientific approach to eczematous skin:

·Unique formulation with combination of ceramides, lactic acid and niacinamide.
·QV Intensive with Ceramides unique dual action helps to restore epidermal barrier function.
·Delivers ceramides (EOP and NP), cholesterol and free fatty acids in the optimum 3:1:1 molar ratio which has been shown to help support and replenish the epidermal barrier.1
·Provides lactic acid and niacinamide, which have been shown to help support synthesis of ceramides from within.2,3
·Increases skin hydration and reduces transepidermal water loss (TEWL).4
·Rehydrates and soothes dry, itchy or damaged skin.4
·Free of preservatives, soap, fragrance and allergens which ensures suitability for patients with eczematous skin.
·Non comedogenic.
·Pediatrician tested.
·Dermatologically and ophthalmologically tested.
·Part of Ego Pharm’s integrated range to help prevent and manage mild-to-moderate eczema.
·Proud Gold Supporter of Eczema Association of Australasia.

Clinical study for QV Intensive with Ceramides
·QV Intensive with Ceramides Cream provide 110% more hydration as compared to similar brands in the market.4 (Figure 1)

Figure 1_QV Intensive with Ceramides

·Reduction in TEWL was observed over 5 days following topical application of QV Intensive with Ceramides Light Moisturising Cream.4 (Figure 2)
Figure 2_QV Intensive with Ceramides

Importance of the 3:1:1 ceramide dominant molar ratio
Ceramides, cholesterol and fatty acids are the predominant lipids in the stratum corneum or skin barrier.2,3 Ceramides must be delivered in the correct ratio with cholesterol and free fatty acids in order for ceramide-containing products to have a positive effect on the barrier function.5 The optimal molar ratio is 3:1:1, with ceramides being the dominant component.3

In order for topical ceramide products to be effective, a correct relative molar ratio of ceramides, cholesterol and fatty acids must be formulated into the right delivery system. Hence, knowledge of skin is as important as knowledge of formulation science. New QV Intensive with Ceramides products have unique formulations which have been designed to ensure delivery of ceramide, cholesterol and fatty acids in an optimal ratio.

References: 1. Rawlings AV, Maibach HI. Advances in Dry Skin Stratum Corneum Biology and Moisturization. In: Maibach HI, ed. A Dermatological View: from Physiology to Therapy. Illinois: Allured books; 2011: 367–380. 2. Rawlings AV, et al. Effect of lactic acid isomers on keratinocyte ceramide synthesis, stratum corneum lipid levels and stratum corneum barrier function. Arch Dermatol Res. 1996;288:383–390. 3. Tanno O, et al. Nicotinamide increases biosynthesis of ceramides as well as other stratum corneum lipids to improve the epidermal permeability barrier. Br J Dermatol. 2000;143:524–531. 4. Data on file; Spada, F, Greive KA and Barnes TM, 2018. In preparation. 5. Chamlin SL, et al. Ceramide-dominant barrier repair lipids alleviate childhood atopic dermatitis: Changes in barrier function provide a sensitive indicator of disease activity. J Am Acad Dermatol 2002:47(2);198–208.

 

 


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Most Read Articles
6 days ago
Electroretinogram-assessed localized retinal dysfunction in type 1 diabetes mellitus patients appears to occur even in the absence of clinical signs of diabetic retinopathy (DR), and this incidence is associated with ageing, according to a study.
Roshini Claire Anthony, 18 hours ago

Patients with mild hypertension who are at low risk for cardiovascular disease (CVD) do not appear to derive mortality or CVD benefit from antihypertensive treatments, raising questions on the need for treatment in this population, according to a recent study from England.

Pearl Toh, 3 days ago
A personalized computerized neurofeedback intervention for training attention and memory shows potential in cognitive training for healthy elderly men, who improved in cognitive performance after the training, although no significant improvements were seen in the overall study population.
6 days ago
Greater home blood pressure (BP) variability, particularly in home systolic (S)BP, correlates with higher carotid, aortic and peripheral but not coronary atherosclerosis burdens independent of the mean home BP, suggests a recent study.