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Market Watch - QV Intensive with Ceramides

01 Sep 2018

QV Intensive with Ceramides
Ego Pharm Malaysia Sdn Bhd

A scientific approach to eczematous skin:

·Unique formulation with combination of ceramides, lactic acid and niacinamide.
·QV Intensive with Ceramides unique dual action helps to restore epidermal barrier function.
·Delivers ceramides (EOP and NP), cholesterol and free fatty acids in the optimum 3:1:1 molar ratio which has been shown to help support and replenish the epidermal barrier.1
·Provides lactic acid and niacinamide, which have been shown to help support synthesis of ceramides from within.2,3
·Increases skin hydration and reduces transepidermal water loss (TEWL).4
·Rehydrates and soothes dry, itchy or damaged skin.4
·Free of preservatives, soap, fragrance and allergens which ensures suitability for patients with eczematous skin.
·Non comedogenic.
·Pediatrician tested.
·Dermatologically and ophthalmologically tested.
·Part of Ego Pharm’s integrated range to help prevent and manage mild-to-moderate eczema.
·Proud Gold Supporter of Eczema Association of Australasia.

Clinical study for QV Intensive with Ceramides
·QV Intensive with Ceramides Cream provide 110% more hydration as compared to similar brands in the market.4 (Figure 1)

Figure 1_Skin Hydration graph

·Reduction in TEWL was observed over 5 days following topical application of QV Intensive with Ceramides Light Moisturising Cream.4 (Figure 2)

Figure 2_TEWL graph

Importance of the 3:1:1 ceramide dominant molar ratio
Ceramides, cholesterol and fatty acids are the predominant lipids in the stratum corneum or skin barrier.2,3 Ceramides must be delivered in the correct ratio with cholesterol and free fatty acids in order for ceramide-containing products to have a positive effect on the barrier function.5 The optimal molar ratio is 3:1:1, with ceramides being the dominant component.3

In order for topical ceramide products to be effective, a correct relative molar ratio of ceramides, cholesterol and fatty acids must be formulated into the right delivery system. Hence, knowledge of skin is as important as knowledge of formulation science. New QV Intensive with Ceramides products have unique formulations which have been designed to ensure delivery of ceramide, cholesterol and fatty acids in an optimal ratio.

References: 1. Rawlings AV, Maibach HI. Advances in Dry Skin Stratum Corneum Biology and Moisturization. In: Maibach HI, ed. A Dermatological View: from Physiology to Therapy. Illinois: Allured books; 2011: 367–380. 2. Rawlings AV, et al. Effect of lactic acid isomers on keratinocyte ceramide synthesis, stratum corneum lipid levels and stratum corneum barrier function. Arch Dermatol Res. 1996;288:383–390. 3. Tanno O, et al. Nicotinamide increases biosynthesis of ceramides as well as other stratum corneum lipids to improve the epidermal permeability barrier. Br J Dermatol. 2000;143:524–531. 4. Data on file; Spada, F, Greive KA and Barnes TM, 2018. In preparation. 5. Chamlin SL, et al. Ceramide-dominant barrier repair lipids alleviate childhood atopic dermatitis: Changes in barrier function provide a sensitive indicator of disease activity. J Am Acad Dermatol 2002:47(2);198–208.

 

 


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Most Read Articles
Tristan Manalac, 4 days ago
The causes, presentations and management of anaphylaxis vary considerably with age, according to a recent Singapore study, which reported that children are more likely to present with food anaphylaxis, while drug anaphylaxis is more common in adults.
Pearl Toh, 3 days ago
Low-density lipoprotein cholesterol (LDL-C) levels remained high in many patients with stable or acute coronary heart disease (CHD) in Asia, despite having a very high risk of recurrent cardiovascular (CV) events, indicating that the use of lipid-lowering therapies and lipid monitoring were inadequate.
13 Sep 2018
Substituting diets high in carbohydrates with those high in monounsaturated fatty acids in the context of low saturated fatty acids do not appear to yield favourable effects on blood pressure, according to a meta-analysis.
2 days ago
There is a strong association between smoking duration and colorectal polyps, independent of smoking intensity, cessation and other potential confounders, reports a recent study. Such association is more robust with distal rather than proximal polyps, and with serrated polyps rather than adenomas.