Most Read Articles
22 hours ago
There appears to be a high rate of emergency department (ED) admission for acute exacerbation of chronic obstructive pulmonary disease (AECOPD), with patients having significant in-hospital mortality, according to data from the *AANZDEM study. Furthermore, compliance with evidence-based treatments in the ED is suboptimal.
Tristan Manalac, 5 days ago
Of the newly identified genetic loci for primary angle-closure glaucoma (PACG), two are significantly associated with primary angle-closure suspect (PACS), indicating involvement in the earlier stages of the disease, a recent Singapore study has shown.
2 days ago
Resistance training appears to confer significant benefits for inflammation and insulin pathway profiles in postmenopausal breast cancer survivors, according to a study. However, the magnitude and degree of benefit from exercise may be influenced by whether or not women gained strength and/or lost weight during exercise.
Pearl Toh, 2 days ago
Patients with inflammatory bowel disease (IBD) who had primary nonresponse to an anti-tumour necrosis factor (TNF) agent ─ or inadequate response to the initial loading doses ─ were less likely to respond to second-line biologics compared with those who had secondary loss of response (LOR) or intolerance to the primary therapy, according to a systematic review and meta-analysis presented at the Crohn's & Colitis Congress (CCC) 2018 held recently in Las Vegas, Nevada, US.

Marijuana use not linked to eGFR changes, albuminuria

13 Nov 2017

High levels of marijuana exposure appears to not be longitudinally associated with prevalent albuminuria and substantial changes in estimated glomerular filtration rate by cystatin C (eGFRcys), a recent US epidemiological study has shown.

The researchers recruited 3,765 adolescents with preserved eGFR and whose cystatin C levels and urinary albumin-to-creatinine ratios were measured at defined intervals. Marijuana use was assessed at defined intervals using a self-administered questionnaire.

Over the 10-year follow-up, 83 percent (n=3,131) of the participants reported either past or current marijuana use, with the mean eGFRcys measured to be 111 mL/min per 1.73 m2. Throughout the duration of the study, the proportion of current marijuana use remained above 15 percent.

Participants with at least 5 years of marijuana use had significantly lower eGFRcys, according to a multivariable analysis adjusted for age, race, sex, employment status, comorbidities and other clinical factors (percent difference, -3.0; 95 percent CI, -5.6 to -0.4; p=0.03).

While the trend between greater marijuana use and lower eGFRcys was statistically significant in the overall sample (p=0.04) and when stratified by race (p=0.03), no dose-response relationship was observed.

In contrast, marijuana use, even in those with at least 5 years of use, was not associated with 5-year changes in eGFRcys, both from years 10 to 15 and 15 to 20 (p=0.82 for trend).

Similarly, both rapid declines in eGFRcys (p=0.66 for trend) and prevalent albuminuria (p=0.41 for trend) were not associated with higher levels of marijuana use.

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Most Read Articles
22 hours ago
There appears to be a high rate of emergency department (ED) admission for acute exacerbation of chronic obstructive pulmonary disease (AECOPD), with patients having significant in-hospital mortality, according to data from the *AANZDEM study. Furthermore, compliance with evidence-based treatments in the ED is suboptimal.
Tristan Manalac, 5 days ago
Of the newly identified genetic loci for primary angle-closure glaucoma (PACG), two are significantly associated with primary angle-closure suspect (PACS), indicating involvement in the earlier stages of the disease, a recent Singapore study has shown.
2 days ago
Resistance training appears to confer significant benefits for inflammation and insulin pathway profiles in postmenopausal breast cancer survivors, according to a study. However, the magnitude and degree of benefit from exercise may be influenced by whether or not women gained strength and/or lost weight during exercise.
Pearl Toh, 2 days ago
Patients with inflammatory bowel disease (IBD) who had primary nonresponse to an anti-tumour necrosis factor (TNF) agent ─ or inadequate response to the initial loading doses ─ were less likely to respond to second-line biologics compared with those who had secondary loss of response (LOR) or intolerance to the primary therapy, according to a systematic review and meta-analysis presented at the Crohn's & Colitis Congress (CCC) 2018 held recently in Las Vegas, Nevada, US.