Most Read Articles
6 days ago
The consumption of red and processed meats does not seem to affect the likelihood of symptom relapse among Crohn’s disease (CD) patients in relapse, reports a recent study.
Pearl Toh, 4 days ago
In addition to the known evils of maternal smoking during pregnancy on the son’s semen quality, prenatal exposure to paternal smoking can also be harmful, according to data from a large Danish National Birth Cohort (DNBC) presented at the ESHRE 2019 Meeting.
6 days ago
Treatment with metformin may improve whole-body and peripheral insulin resistance (IR) in youth who are overweight/obese with type 1 diabetes (T1D), according to a study.
4 days ago
Fluticasone, swallowed from a multidose inhaler, and oral viscous budesonide slurry have comparable efficacies as initial treatment for eosinophilic oesophagitis, a recent study has found.

Marijuana may prevent digestive organ disorders in schizophrenia

11 Apr 2019

Cannabis use disorder (CUD) appears to exert a beneficial effect on the risk of disorders of gut–brain interaction and inflammatory bowel disease (IBD) in patients with schizophrenia but not in population controls, a study has found. This finding raises the possibility of new targets for treatment and prevention of digestive organ disorders in schizophrenia.

In the study, researchers combined nationwide Danish registers and identified 21,066 patients with schizophrenia and 176,935 sex-and-age-matched controls. They constructed two time-varying Cox regression models to examine the associations between CUD and digestive disorders.

CUD showed a protective association with the risk of developing disorders of gut–brain interaction, such as IBD and dyspepsia, among patients with schizophrenia (hazard ratio [HR], 0.84; 95 percent CI, 0.74–0.94; p=0.003).

The beneficial effect of CUD on the risk of IBD was significant in the basically adjusted model (HR, 0.70; CI, 0.49–0.99; p=0.045) and dropped just below statistical significance in the fully adjusted model (HR, 0.71; 0.48–1.03; p=0.07).

Furthermore, CUD exhibited a tendency toward a reduced risk of serious disorders of the digestive organs in the schizophrenia group (HR, 0.89; 0.77–1.02; p=0.09) in the fully adjusted model.

The relationships were not seen among controls.

Researchers emphasized the need to conduct additional studies to replicate the current data and explore the exact mechanisms of the associations. Consequently, even if the findings are ultimately considered true, clinical use of cannabis for patients with schizophrenia still needs to weigh the potential benefits against the potential harms, given the range of known detrimental effects of substance.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
6 days ago
The consumption of red and processed meats does not seem to affect the likelihood of symptom relapse among Crohn’s disease (CD) patients in relapse, reports a recent study.
Pearl Toh, 4 days ago
In addition to the known evils of maternal smoking during pregnancy on the son’s semen quality, prenatal exposure to paternal smoking can also be harmful, according to data from a large Danish National Birth Cohort (DNBC) presented at the ESHRE 2019 Meeting.
6 days ago
Treatment with metformin may improve whole-body and peripheral insulin resistance (IR) in youth who are overweight/obese with type 1 diabetes (T1D), according to a study.
4 days ago
Fluticasone, swallowed from a multidose inhaler, and oral viscous budesonide slurry have comparable efficacies as initial treatment for eosinophilic oesophagitis, a recent study has found.