Most Read Articles
Roshini Claire Anthony, 09 Oct 2020

The risk of falls and subsequent injuries (eg, fractures) may be elevated in individuals with diabetes compared with the general population, according to a nationwide cohort study from Denmark.

Audrey Abella, 10 Sep 2020
Interim results of REGENERATE* trial highlight the ability of experimental noninvasive tests to evaluate treatment response in adults with NASH** and advanced liver fibrosis who are receiving obeticholic acid (OCA).
Rachel Soon, 28 Aug 2020
MOH Director-General Tan Sri Dato' Seri Dr Noor Hisham Abdullah speaks about NHMS 2019 and pharmacists' roles in combating NCDs among Malaysians.
02 Jul 2019
A systematic review has recently described the rudimentary pharmacokinetics of mitragynine, but studies lack information on the role of metabolism and redistribution into tissues or excretion rate.

Margetuximab shows synergy with pembrolizumab in gastro-oesophageal adenocarcinoma

03 Aug 2020

When combined with the anti-PD-1 checkpoint inhibitor pembrolizumab, the investigational anti-HER2 monoclonal antibody margetuximab demonstrates synergistic antitumour activity against HER2 gastro-oesophageal adenocarcinoma, according to the results of a phase Ib–II trial.

Conducted at centres in the US, Canada, and Asia (Korea, Taiwan, and Singapore), the trial included 95 patients with histologically proven, unresectable, locally advanced or metastatic, HER2-positive, PD-L1-unselected gastro-oesophageal adenocarcinoma. All patients had progressed after at least one previous line of therapy with trastuzumab plus chemotherapy.

In the dose-escalation phase, three patients received infusions of margetuximab 10 mg/kg, while six patients received the recommended dose of 15 mg/kg, in addition to intravenous pembrolizumab 200 mg every 3 weeks. Eighty-six patients were included in the cohort expansion and received the recommended margetuximab dose.

Over a median follow-up of 19.9 months, the combination therapy showed acceptable safety and tolerability; no dose-limiting toxicities were recorded in the dose-escalation phase. The most common grade 3–4 treatment-related adverse events were anaemia (n=4) and infusion-related reactions (n=3).

Nine patients developed serious treatment-related adverse events. There were no reports of treatment-related deaths.

Of the 92 evaluable patients, 17 showed objective response and 49 achieved disease control. The median progression-free survival was 2.73 months, and median overall survival was 12.48 months. The presence of HER2 amplification in ctDNA (n=48) was associated with better response (odds ratio, 7.3, 95 percent confidence interval, 1.5–71.4).

Based on the findings, the combination of margetuximab and pembrolizumab might offer a new chemotherapy-free treatment option for patients with gastro-oesophageal adenocarcinoma, researchers said. A phase II–III MAHOGANY study is underway to investigate the safety and efficacy of margetuximab plus checkpoint inhibitors with or without chemotherapy in the first-line setting.

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Most Read Articles
Roshini Claire Anthony, 09 Oct 2020

The risk of falls and subsequent injuries (eg, fractures) may be elevated in individuals with diabetes compared with the general population, according to a nationwide cohort study from Denmark.

Audrey Abella, 10 Sep 2020
Interim results of REGENERATE* trial highlight the ability of experimental noninvasive tests to evaluate treatment response in adults with NASH** and advanced liver fibrosis who are receiving obeticholic acid (OCA).
Rachel Soon, 28 Aug 2020
MOH Director-General Tan Sri Dato' Seri Dr Noor Hisham Abdullah speaks about NHMS 2019 and pharmacists' roles in combating NCDs among Malaysians.
02 Jul 2019
A systematic review has recently described the rudimentary pharmacokinetics of mitragynine, but studies lack information on the role of metabolism and redistribution into tissues or excretion rate.