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Managing pneumonia in primary care

26 Jun 2019

Assoc Prof Philip Eng, senior consultant respiratory physician at Mt Elizabeth Hospital in Singapore, shares his insights with Pearl Toh on diagnosing and managing pneumonia in the primary care setting.

Assoc Prof Philip Eng, Mt Elizabeth Hospital, Singapore

Assoc Prof Philip Eng, Mt Elizabeth Hospital, Singapore

Pneumonia is the second commonest cause of death in Singapore and most developed countries, accounting for 20 percent of all deaths in Singapore in 2017. The commonest cause of death is cancer and the third is ischaemic heart disease. Bacteria, viruses, and fungi infections can all cause pneumonia.

Diagnosing pneumonia 
The main symptoms to look out for are cough and fever. Occasionally, there is pleuritic chest pain and shortness of breath. If the sputum is purulent (dark with either a yellow or green tinge), it often points to a bacterial aetiology while mucoid sputum (white and frothy) or an unproductive cough suggest a viral aetiology or an atypical pneumonia.

However, this rule does not always hold true. On physical examination, signs to look out for include fever, tachycardia, tachypnoea, and an abnormal chest auscultation. Specifically, listen out for crepitations and rhonchi. If pneumonia is suspected, the usual test to do is a chest X-ray to confirm the diagnosis of pneumonia.

Challenges
The main challenge for a GP is to differentiate an upper respiratory tract infection from a lower respiratory tract infection. Taking careful note of the patient’s history is important to help differentiate between the two conditions.

Most upper respiratory tract infections are innocuous and resolve in a few days and do not require antibiotics as they are usually due to viruses. Upper respiratory tract infections usually do not result in severe sequelae like hospitalization or death. In contrast, lower tract infections such as pneumonia may have a potential to cause death or hospitalization.

The second tip is to examine the chest carefully through auscultation. If a lower respiratory tract infection is suspected, one should order a chest X-ray (posteroanterior [PA] and left lateral) to confirm the diagnosis of pneumonia. The left lateral is often forgotten but it gives valuable information of the left lower lobe which is shielded by the heart during a conventional PA chest X-ray.

Another tip is to pay attention to red flags in the patient’s history, eg, hemoptysis, weight loss, or prolonged cough (>3 weeks). Any patient who coughs for more than 3 weeks should have a chest X-ray to rule out anything sinister. The list of differential diagnoses of pneumonia are wide and commonly include lung cancer, lymphoma, acute pulmonary embolism, and bronchiectasis, among others.

In addition, one should always be on the lookout for influenza. Influenza is one of the top three aetiological causes of adult community-acquired pneumonia in major studies globally. In children, it is amongst the top 10. Such patient usually presents acutely with high fever (>38.5oC), cough, rhinitis, sore throat, and body aches. Influenza can become a very severe illness in a few days if it goes to the lungs and can cause multi-organ failure. An example of a chest X-ray of a 50-year-old adult with influenza pneumonia is shown in Image 1, depicting bilateral lung infiltrates; symptoms on presentation include fever, cough, and shortness of breath.

Managing pneumonia Image-01

The other important thing about influenza is that there is a very narrow window of therapeutic opportunity as usual medications, such as the antiviral oseltamivir, are most effective only if given within 48 hours of symptom onset.

Primary care practitioners play an important role in preventing the development of influenza and pneumococcal pneumonia. Risk factors for developing such diseases are listed in Tables 1 and 2 and vaccination should be offered to high-risk patients.
Managing pneumonia Table-01
Managing pneumonia Table-02

Treating pneumonia
The key aim of treatment is to achieve a good clinical outcome — prevent death or hospitalization.

Besides symptomatic treatment, the mainstay of treatment for pneumonia is antibiotics. If the patient has an influenza pneumonia, the usual treatment is to give antivirals early.

Additional points to emphasize when treating pneumonia are listed below:
• beware of using quinolones in suspected respiratory tract infections unless tuberculosis is ruled out. Quinolones can mask the symptoms and delay the diagnosis of tuberculosis;
• beware of overdiagnosing mycoplasma infection. The correct method is to test for Mycoplasma pneumoniae IgM. There is also no need for extended use of the usual antibiotics such as tetracyclines or macrolides.

Challenges
Further to what was discussed above, the next challenge after diagnosing pneumonia in the primary care setting is to decide whether to treat or to refer to a specialist.

The first aspect to consider is the presence of risk factors such as chronic illnesses or elderly age (≥65 years). Those with severe pneumonia (eg, breathless or very sick patients), who are very elderly, or with multiple comorbid conditions should be referred to a specialist early for further work-up or treatment. Examples of comorbidities or chronic illness requiring specialist’s evaluation include stroke/neurological illness (such as Parkinson’s disease), chronic severe heart disease, renal failure, cancer, HIV, asthma, and chronic obstructive pulmonary disease. Being on long-term immunosuppressive drugs such as steroids also warrants referral to a specialist.

Such patients have less immune reserve and are prone to infections caused by unusual pathogens that need to be identified concurrently during treatment.

Sometimes it may not be evident initially but often patients with HIV have pneumonia as the first presentation, without themselves knowing they are HIV-positive. These patients definitely need specialist care.

Referral to a specialist also applies to the following groups: patients who have not improved following initial treatment, those whose diagnosis is in doubt, those with red flag symptoms (such as hemoptysis, weight loss, prolonged symptoms), those who are in contact with others with similar symptoms, or any patient a GP feels uncomfortable treating himself.

The second aspect is to evaluate if the patient is ill. Experience counts in this aspect, but presence of tachycardia or shortness of breath are tell-tale signs to look out for. Patients who require inpatient hospitalization care also warrants care from a specialist.

In the event that a GP has initiated treatment for pneumonia as an outpatient, it is prudent to follow up on the patient until he/she has completely recovered clinically and radiographically.

Conclusion
Most patients with pneumonia can be treated quite easily with a good outcome. Family practitioners should also be on the lookout for new emerging infections presenting like pneumonia in a returning traveller. SARS in 2003 and the H1N1 influenza epidemic in 2009 are classic examples of viral illnesses causing pneumonia that can spread like wildfire in days.
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Most Read Articles
29 Nov 2019
Metformin Extended Release 500 mg,750 mg, and 1000 mg
30 Nov 2018
New drug applications approved by US FDA as of 16 - 30 November 2018 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.
Elvira Manzano, Roshini Claire Anthony, 01 Oct 2019

The European Society of Cardiology (ESC) has released five new guidelines at the ESC Congress 2019, recommending an even lower LDL-C* target in patients at very high risk for cardiovascular disease (CVD), and the use of SGLT2** inhibitors and GLP-1*** receptor agonists as first-line treatments in those with diabetes to reduce their CVD risk.

Roshini Claire Anthony, 16 Dec 2016

Five years of extended therapy with the aromatase inhibitor (AI) letrozole did not improve survival in postmenopausal breast cancer patients, according to findings of the NRG Oncology/NSABP B-42 trial presented at the San Antonio Breast Cancer Symposium (SABCS 2016) held in Texas, US.