Management of febrile neutropenia in solid organ malignancies following chemotherapy
14 Oct 2014
72 out of 92 patients with high risk neutropenic episodes were studied. They received first-line chemotherapy for locally advanced disease. The most common microbes identified were E. coli and Staphylococcus aureus in blood, Klebsiella pneumonia in sputum and E. coli in urine culture. Cefoperazone-sulbactam was used as an initial empiric antibiotic and piperacillin/tazobactam or carbapenems were added to the patients who did not respond to initial antibiotic. Based on findings, cephaperazone-sulbactum can be an initial choice for empirical therapy in high risk febrile neutropenic patients in solid organ malignancies.