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Pearl Toh, 22 Oct 2020
The combination therapy comprising carfilzomib, cyclophosphamide and dexamethasone (KCd) is effective, with a tolerable safety profile, in an Asian cohort with high-risk multiple myeloma (MM) — thus providing a more economical alternative as a potential upfront regimen in resource-limited settings, according to leading experts during a myeloma education webinar.
Pearl Toh, 21 Sep 2020
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
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Male pattern baldness not indicative of prostate cancer risk, progression

12 Jun 2020

Baldness has little to do with the risk of prostate cancer, overall or specific clinical or molecular markers, according to a study.

Researchers prospectively examined the association between baldness (self-reported via the modified Norwood–Hamilton scale) at age 45 years and prostate cancer risk among 36,760 men from the Health Professionals Follow-up Study (HPFS). Of the men, 16,070 (44 percent) reported no balding, 9,374 (25 percent) frontal balding, 6,300 (17 percent) frontal and mild vertex balding, 2,929 (8 percent) frontal and moderate vertex balding, and 2,087 (6 percent) frontal and severe vertex balding.

Compared with those who did not have hair loss, men who reported frontal and severe vertex baldness were slightly shorter, had a higher body mass index at age 21 years, and were less likely to be current smokers.

Over 22 years of follow-up, 5,157 men developed prostate cancer. There were no significant associations seen between any baldness patterns and prostate cancer risk.

Among men aged <60 years, frontal and severe vertex baldness pattern showed a statistically significant association with overall prostate cancer (hazard ratio, 1.74, 95 percent confidence interval, 1.23–2.48).

Baldness was not related to prostate cancer defined by tumour protein expression of androgen receptor and the presence of the TMPRSS2:ERG fusion.

Common risk factors, such as age and endogenous hormone levels, potentially explain an association between male pattern baldness and prostate cancer, the researchers noted. However, the null findings from the current study, along with inconclusive data from prior reports, suggest that baldness is not a consistent biomarker for prostate cancer risk or progression.
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Most Read Articles
Pearl Toh, 22 Oct 2020
The combination therapy comprising carfilzomib, cyclophosphamide and dexamethasone (KCd) is effective, with a tolerable safety profile, in an Asian cohort with high-risk multiple myeloma (MM) — thus providing a more economical alternative as a potential upfront regimen in resource-limited settings, according to leading experts during a myeloma education webinar.
Pearl Toh, 21 Sep 2020
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
3 days ago
Weight suppression appears to result in future onset of eating disorders characterized by dietary restriction or compensatory weight control behaviours, suggesting weight-suppressed women represent an at-risk group that may benefit from selective prevention programmes, a study has found.
4 days ago
Nocturia is a risk factor for mortality, according to the results of the Nagahama Study, which boasts of a low incidence of missing data and high representation of the general population.