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Male pattern baldness not indicative of prostate cancer risk, progression

12 Jun 2020

Baldness has little to do with the risk of prostate cancer, overall or specific clinical or molecular markers, according to a study.

Researchers prospectively examined the association between baldness (self-reported via the modified Norwood–Hamilton scale) at age 45 years and prostate cancer risk among 36,760 men from the Health Professionals Follow-up Study (HPFS). Of the men, 16,070 (44 percent) reported no balding, 9,374 (25 percent) frontal balding, 6,300 (17 percent) frontal and mild vertex balding, 2,929 (8 percent) frontal and moderate vertex balding, and 2,087 (6 percent) frontal and severe vertex balding.

Compared with those who did not have hair loss, men who reported frontal and severe vertex baldness were slightly shorter, had a higher body mass index at age 21 years, and were less likely to be current smokers.

Over 22 years of follow-up, 5,157 men developed prostate cancer. There were no significant associations seen between any baldness patterns and prostate cancer risk.

Among men aged <60 years, frontal and severe vertex baldness pattern showed a statistically significant association with overall prostate cancer (hazard ratio, 1.74, 95 percent confidence interval, 1.23–2.48).

Baldness was not related to prostate cancer defined by tumour protein expression of androgen receptor and the presence of the TMPRSS2:ERG fusion.

Common risk factors, such as age and endogenous hormone levels, potentially explain an association between male pattern baldness and prostate cancer, the researchers noted. However, the null findings from the current study, along with inconclusive data from prior reports, suggest that baldness is not a consistent biomarker for prostate cancer risk or progression.
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Most Read Articles
2 days ago
High-frequency use of cannabis appears to worsen clinical pain and associated symptoms among chronic pain patients, a recent study has found.
Jairia Dela Cruz, 5 days ago
In patients with heart failure with reduced ejection fraction (HFrEF) receiving angiotensin-converting-enzyme (ACE) inhibitors, high dosing confers benefits for the risk of death or hospitalization that are similar to that obtained with lower dosing, according to a systematic review and meta-analysis.
Yesterday
Women with pre-eclampsia are at higher risk of developing heart failure, a study suggests.
06 Sep 2020
Type 2 diabetes mellitus patients taking proton pump inhibitors (PPIs) are at a higher risk of sustaining hip fractures, a recent study has found.